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Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

DOI :

10.3791/53789-v

January 19th, 2016

January 19th, 2016

9,659 Views

1Department of Chemistry, State University of New York at Stony Brook, 2Institute of Chemical Biology and Drug Discovery, State University of New York at Stony Brook

An operationally simple procedure for the synthesis of ortho-trifluoromethoxylated aniline derivatives via a two-step sequence of O-trifluoromethylation of N-aryl-N-hydroxyacetamide followed by thermally induced intramolecular OCF3-migration is reported.

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Ortho trifluoromethoxylated Aniline Derivatives

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