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A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products

DOI :

10.3791/53593-v

September 9th, 2016

September 9th, 2016

10,328 Views

1Department of Chemistry, Central Washington University, 2Department of Chemistry, Utah Valley University

Here, we present a protocol for direct, early stage guanidinylation that enables rapid total synthesis of aminoguanidine-containing small organic molecules. An advanced synthetic intermediate used in the synthesis of a blood coagulation factor XIa inhibitor was prepared using this protocol.

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Keywords Guanidinylation

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