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Whole-cell Patch-clamp Recordings in Brain Slices

DOI :

10.3791/54024-v

June 15th, 2016

June 15th, 2016

54,480 Views

1Department of Psychiatry, University of Texas Southwestern Medical Center

This protocol describes basic procedural steps for performing whole-cell patch-clamp recordings. This technique allows the study of the electrical behavior of neurons, and when performed in brain slices, allows the assessment of various neuronal functions from neurons that are still integrated in relatively well preserved brain circuits.

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