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Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes

DOI :

10.3791/54106-v

July 23rd, 2016

July 23rd, 2016

9,946 Views

1Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University

The goal of this protocol is to use cationic/anionic liposomes with a neuro-targeting peptide as a CNS delivery system to enable siRNA to cross the BBB. The optimization of a delivery system for treatments, like siRNA, would allow for more treatment options for prion and other neurodegenerative diseases.

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