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Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

DOI :

10.3791/54128-v

6:09 min

June 22nd, 2016

June 22nd, 2016

21,819 Views

1Translational Immunology, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, 2Singapore Immunology Network, 3Institute of Biomedical Studies, Baylor University

Immature dendritic cells can be selectively differentiated into tolerogenic or mature dendritic cells to regulate the balance between immunity and tolerance. This work presents a means to generate from immature monocyte derived dendritic cells (moDCs), in vitro tolerogenic and mature moDCs that differ in metabolic phenotypes.

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