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Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps

DOI :

10.3791/54215-v

10:19 min

August 14th, 2016

August 14th, 2016

8,880 Views

1Department of Pharmacology, Université de Montréal, 2Department of Neuroscience, Université de Montréal, 3Hôpital du Sacré-coeur de Montréal Research Center, Université de Montréal

To study the effects of Aβo in vivo, we developed a model based on repeated hippocampal infusions of soluble Aβo coupled with continuous infusion of Aβo antibody (6E10) in the hippocampus using osmotic pumps to counteract the neurotoxic effect of Aβo.

Tags

Neurodegeneration

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