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JoVE Journal

Genetics

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Measurement of Differentially Methylated INS DNA Species in Human Serum Samples as a Biomarker of Islet β Cell Death

Transcript

The overall goal of this procedure is to measure differentially methylated preproinsulin DNA species in human serum as a biomarker of beta cell death. This method can help answer key questions in the diabetes field, such as, is beta cell death occ

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Islet β cell death precedes development of type 1 diabetes, and detecting this process may allow for early therapeutic intervention. Here, we provide a detailed description of how to measure differentially methylated INS DNA species in human serum as a biomarker of β cell death.

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