Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses

9.8K Views

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09:07 min

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January 20th, 2017

DOI :

10.3791/55235-v

January 20th, 2017

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Con Sullivan¹^,², Denise Jurcyzszak¹, Michelle F. Goody³, Kristin A. Gabor⁴, Jacob R. Longfellow¹, Paul J. Millard²^,⁵, Carol H. Kim¹^,²

¹Department of Molecular and Biomedical Sciences, University of Maine, ²Graduate School of Biomedical Sciences and Engineering, University of Maine, ³School of Biology and Ecology, University of Maine, ⁴Division of Intramural Research, Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, ⁵Department of Chemical and Biological Engineering, University of Maine

Summary

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Posterior Cardinal Vein

Circulatory System

Systemic Infection

Chapters in this video

0:05

Title

0:44

Systemic Influenza A Virus Infection at 48 Hr Post Fertilization

3:07

Localized, Swim Bladder IAV Infection of Tg(mpx:mCherry) Transgenic Zebrafish

4:19

Anti-viral Drug Treatment

5:23

Mounting Zebrafish for Imaging

6:39

Results: Anti-viral Drug Treatment of IAV Infection in Zebrafish

8:25

Conclusion

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