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Drug Screening of Primary Patient Derived Tumor Xenografts in Zebrafish

DOI :

10.3791/60996-v

April 10th, 2020

April 10th, 2020

7,557 Views

1Department of Molecular and Cellular Biochemistry, University of Kentucky, 2Markey Cancer Center, University of Kentucky

Zebrafish xenograft models allow for high-throughput drug screening and fluorescent imaging of human cancer cells in an in vivo microenvironment. We developed a workflow for large scale, automated drug screening on patient-derived leukemia samples in zebrafish using an automated fluorescence microscope equipped imaging unit.

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Drug Screening

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