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In Situ Microscopy for Real-time Determination of Single-cell Morphology in Bioprocesses

DOI :

10.3791/57823-v

December 5th, 2019

December 5th, 2019

7,658 Views

1Chair of Bioprocess Engineering, Department of Biotechnology, Technische Universität Berlin, 2SOPAT GmbH

A photo-optical in situ microscopy device was developed to monitor the size of single cells directly in the cell suspension. The real-time measurement is conducted by coupling the photo-optical sterilizable probe to an automated image analysis. Morphological changes appear with dependence on the growth state and cultivation conditions.

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Keywords In Situ Microscopy

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