Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension

2.9K Views

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07:41 min

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March 17th, 2022

DOI :

10.3791/58057-v

March 17th, 2022

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David Boulate¹, Myriam Amsallem¹^,², Jean-Baptiste Menager¹, Simon Dang Van¹, Peter Dorfmuller³, Andrew Connolly⁴, Alban Todesco⁵, Benoit Decante¹, Elie Fadel¹, Francois Haddad², Olaf Mercier¹

¹Research and Innovation Unit, RHU BioArt Lung 2020, Marie Lannelongue Hospital, ²Phenotypic and Biomarker Core Laboratory, Cardiovascular Institute, Stanford University, ³Department of pathology, Marie Lannelongue Hospital, ⁴Department of pathology, UCSF School of Medicine, ⁵Department of thoracic surgery, Hopital Nord, APHM, Aix-Marseille University

Summary

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Keywords Acute Right Heart Failure

Chronic Thromboembolic Pulmonary Hypertension

Balloon Dilation Catheter

Echocardiography

Tissue Doppler

Right Heart Catheterization

Swan Ganz Catheter

Thermodilution

Pressure volume Loop

Chapters in this video

0:04

Introduction

0:39

Catheter Placement

1:44

Echocardiography

2:19

Right Heart Catheterization and Pressure Volume Loop Acquisition

3:20

Acute Right Heart Failure Induction

3:58

Pressure Overload with Iterative Pulmonary Embolism Induction

4:40

Systemic Hemodynamic Restoration

5:30

Results: Representative Acute Right Heart Failure Phenotype Analyses

7:07

Conclusion

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