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A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy

DOI :

10.3791/58567-v

January 30th, 2019

January 30th, 2019

13,368 Views

1Chemistry, University of Southampton, 2Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca

A novel and straightforward variation of the shake-flask method was developed for accurate lipophilicity measurement of fluorinated compounds by 19F NMR spectroscopy.

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