Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
8.3K Views
•
09:24 min
•
August 22nd, 2017
DOI :
August 22nd, 2017
•Chapters in this video
0:05
Title
0:51
Preparation of Samples and NMR Instrument for 19F TD-NMR Measurement
1:56
Measurement of the T1 or Longitudinal Relaxation Time for Standard Pure API Samples
3:23
Measuring Calibration Samples with Pure API
4:29
Measuring Drug Product Samples as Tablets
4:59
Generation of Calibration Curves with Pure API Samples and Adding the Data from Drug Product Samples as Tablets in the Calibration Curve
6:59
Calculation of the Fluorinated API Drug Weight in the Formulated Drug Product Using the Calibration Curves
7:33
Results: Evaluation of the Average Drug Content of Cinacalcet in Tablet Dosage Forms by Low-field Fluorine-19 Time-domain Nuclear Magnetic Resonance
8:29
Conclusion
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