JoVE Logo
Faculty Resource Center

Sign In

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

DOI :

10.3791/59155-v

February 7th, 2019

February 7th, 2019

6,725 Views

1School of Basic Medical Sciences, Lanzhou University, 2School of Pharmaceutical Sciences, Sun Yat-sen University

Enantiomerically enriched bispiro[γ-butyrolactone-pyrrolidin-4,4'-pyrazolone] skeletons are asymmetrically synthesized through a simple organocatalytic 1,3-dipolar cycloaddition reaction.

Tags

Organocatalytic Cycloadditions

-- Views

Related Videos

article

Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization

article

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

article

Construction of Models for Nondestructive Prediction of Ingredient Contents in Blueberries by Near-infrared Spectroscopy Based on HPLC Measurements

article

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry

article

The Preparation and Properties of Thermo-reversibly Cross-linked Rubber Via Diels-Alder Chemistry

article

A Simple and Efficient Protocol for the Catalytic Insertion Polymerization of Functional Norbornenes

article

Fabrication and Testing of Catalytic Aerogels Prepared Via Rapid Supercritical Extraction

article

Synthesis of Substrate-Bound Au Nanowires Via an Active Surface Growth Mechanism

article

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile

article

Experimental Methods for Efficient Solar Hydrogen Production in Microgravity Environment

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved