JoVE Logo
Faculty Resource Center

Sign In

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

DOI :

10.3791/58508-v

February 6th, 2019

February 6th, 2019

6,456 Views

1Department of Biology and Chemistry, Azusa Pacific University

Here we present a protocol to demonstrate an efficient method for the synthesis of spirocyclic heterocycles. The five-step process utilizes solid-phase synthesis and regenerating Michael linker strategies. Generally difficult to synthesize, we present a customizable method for the synthesis of spirocyclic molecules otherwise inaccessible to other modern approaches.

-- Views

Related Videos

article

Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters

article

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology

article

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities

article

Synthesis and Characterization of Supramolecular Colloids

article

Hydroquinone Based Synthesis of Gold Nanorods

article

Synthesis of Hierarchical ZnO/CdSSe Heterostructure Nanotrees

article

Integration of Miniaturized Solid Phase Extraction and LC-MS/MS Detection of 3-Nitrotyrosine in Human Urine for Clinical Applications

article

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

article

Synthesis of Substrate-Bound Au Nanowires Via an Active Surface Growth Mechanism

article

Synthesis and Characterization of Amphiphilic Gold Nanoparticles

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved