Bone Morphogenetic Protein-2 (rhBMP-2)-Soaked Sponge Scaffold and Surgical Preparation
1:54
Segmental Femoral Defect Induction
5:50
Results: Representative Segmental Femoral Defect Bone Recovery Analyses
7:21
Conclusion
Transcript
This surgical protocol uses a consistent and reproducible externally fixed segmental defect model to evaluate the healing mechanisms of bone and the use of potential regenerative therapies. We have streamlined a challenging surgery for the creatio
Sign in or start your free trial to access this content
In vivo mammalian models of critical-sized bone defects are essential for researchers studying healing mechanisms and orthopedic therapies. Here, we introduce a protocol for the creation of reproducible, segmental, femoral defects in rats stabilized using external fixation.