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Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis

DOI :

10.3791/52940-v

6:38 min

October 12th, 2016

October 12th, 2016

9,687 Views

1Laboratoire de Bioingénierie et Biomécanique Ostéo-Articulaires (B2OA - UMR CNRS 7052), Université Paris Diderot, 2Ecole Nationale Vétérinaire d’Alfort, Université Paris-Est

Although mouse models are invaluable tools for bone tissue engineering, models of long bone defects are sparse. This need motivated development of the present protocol which uses a locking plate with four screws and a dedicated jig to perform and stabilize a reproducible, femoral, critical-size defect with low morbidity.

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Segmental Femoral Critical size Defect Model

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