Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

DOI :

10.3791/60296-v

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12:28 min

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June 3rd, 2020

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16,585 Views

Tino Emanuele Poloni^1,4*, Valentina Medici^1*, Arenn Faye Carlos¹, Annalisa Davin², Arcangelo Ceretti¹, Michela Mangieri¹, Paola Cassini^1,4, Roberta Vaccaro³, Daniele Zaccaria³, Simona Abbondanza³, Matteo Bordoni⁵, Valentina Fantini^2,6, Elena Fogato⁷, Cristina Cereda⁵, Mauro Ceroni⁸, Antonio Guaita^1,2,3

¹Department of Neurology and Neuropathology, Golgi-Cenci Foundation, ²Laboratory of Neurobiology and Neurogenetic, Golgi-Cenci Foundation, ³Department of Neuropsychology and Social Sciences, Golgi-Cenci Foundation, ⁴Department of Rehabilitation, ASP Golgi-Redaelli Geriatric Hospital, ⁵Genomic and Post-Genomic Center, IRCCS Mondino Foundation, ⁶Department of Brain and Behavioral Sciences, University of Pavia, ⁷Department of Pathology, ASP Golgi-Redaelli Geriatric Hospital, ⁸Department of Neurological Science, IRCCS Mondino Foundation, University of Pavia

Chapters

This protocol describes a method to track individual brain-aging trajectories through a brain donation program and proper characterization of brains. Brain donors are involved in a long-term longitudinal study including serial multi-dimensional assessments. The protocol contains a detailed description of brain processing and an accurate diagnostic methodology.

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