High-grade gliomas such as diffused intrinsic pontine glioma are highly invasive tumors with a high mortality. Despite years of extensive research, the blood-brain barrier is an important aspect because chemotherapy is not able to effectively reac
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The blood-brain barrier (BBB) can be temporarily disrupted with microbubble-mediated focused ultrasound (FUS). Here, we describe a step-by-step protocol for high-throughput BBB opening in vivo using a modular FUS system accessible for non-ultrasound experts.