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Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

DOI :

10.3791/61322-v

August 30th, 2020

August 30th, 2020

9,376 Views

1University of Rouen Normandy, INSERM U1239, DC2N, Institute for Research and Innovation in Biomedicine (IRIB), Rouen, France, 2Department of Anesthesiology and Critical Care, Rouen University Hospital, Rouen, France

We described in this protocol a standardized subarachnoid hemorrhage (SAH) mouse model by a double injection of autologous whole-blood into the cisterna magna. The high degree of standardization of the double-injection procedure represents a middle-to-acute model of SAH with relative safety regarding mortality.

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