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JoVE Journal

Medicine

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Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access

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05:04 min

November 19th, 2020

November 19th, 2020

4,014 Views

0:04

Introduction

0:50

Surgery Preparation

1:27

Stent Implantation

3:57

Results: Representative Stent Implantation Outcome Evaluation

4:37

Conclusion

Transcript

This protocol uses an animal model to establish an accessible method for characterizing the effects of human coronary stents on vascular pathology. The main advantages of our model are that is minimally invasive, highly reproducible, and easily pe

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This protocol describes the implantation of human coronary stents into the abdominal aorta of rats with an apoE-/- background using a trans-femoral access. Compared with other animal models, murine models carry the advantages of high throughput, reproducibility, ease of handling and housing, and a broad availability of molecular markers.

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