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Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

DOI :

10.3791/62325-v

5:00 min

March 3rd, 2021

March 3rd, 2021

2,490 Views

1School of Biomedical Sciences and Pharmacy, University of Newcastle, 2Department of Neurology, John Hunter Hospital, Hunter New England Local Health District

This article describes two methods of whole-body short-duration hypothermia induction in rats. The first, rapid induction method, employs active cooling using fans and ethanol spray for a rapid decrease in temperature. The second method is a gradual cooling method. This is achieved using the combination of isoflurane anesthesia and the reduction of temperature settings on the homeothermic heat mat. This results in a gradual decrease in core body temperature without the use of any external cooling devices. 

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Hypothermia Induction

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