Lipid Imaging and Application of Topical Formulation
3:11
Experimental Setup for Drug Quantification and Data Analysis
8:53
Results: Analysis of the Skin for Tissue Movement and Concentration of Drug at Different Timepoints
10:28
Conclusion
Transcript
This methodology is significant in that it allows for reproducible and accurate method to quantify topically-applied drug products using coherent Raman imaging. Other methodologies provide bulky cutaneous pharmacokinetic information, while this me
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A coherent Raman scattering imaging methodology to visualize and quantify pharmaceutical compounds within the skin is described. This paper describes skin tissue preparation (human and mouse) and topical formulation application, image acquisition to quantify spatiotemporal concentration profiles, and preliminary pharmacokinetic analysis to assess topical drug delivery.