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Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies

DOI :

10.3791/50331-v

April 29th, 2013

April 29th, 2013

12,769 Views

1Department of Neurology, University of Michigan , 2Department of Internal Medicine, University of Michigan

In order to study the changes of nociceptive intraepidermal nerve fibers (IENFs) in painful neuropathies (PN), we developed protocols that could directly examine three-dimensional morphological changes observed in nociceptive IENFs. Three-dimensional analysis of IENFs has the potential to evaluate the morphological changes of IENF in PN.

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