A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats

2.8K Views

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07:41 min

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March 1st, 2022

DOI :

10.3791/63502-v

March 1st, 2022

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Pengchao Sang¹^,²^,³, Mariya M. Kucherenko¹^,²^,³, Juquan Yao², Qiuhua Li², Szandor Simmons²^,³, Wolfgang M. Kuebler*²^,³, Christoph Knosalla*¹^,³^,⁴

¹Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin (DHZB), ²Institute of Physiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, ³DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, ⁴Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health

Summary

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Reverse Vascular Remodeling

Pulmonary Hypertension

Physiological Mechanisms

Right Ventricle

Tracheotomy

Anesthetized Rat

Mechanical Ventilator

Perioperative Lung Ventilation

Chapters in this video

0:05

Introduction

0:42

Surgical Preparations and Tracheotomy and Mechanical Ventilation

2:24

Aortic Debanding

4:06

Tracheal Extubation and Post-Operative Care

5:19

Results: Analysis of Aortic Blood Flow, Ventricular Function, and Hemodynamics after Debanding Surgery

7:09

Conclusion

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