High-Resolution Neutron Spectroscopy to Study Picosecond-Nanosecond Dynamics of Proteins and Hydration Water

1.6K Views

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08:48 min

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April 28th, 2022

DOI :

10.3791/63664-v

April 28th, 2022

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Kevin Pounot¹^,², Markus Appel², Christian Beck¹^,², Martin Weik³, Giorgio Schirò³, Yann Fichou⁴, Tilo Seydel², Frank Schreiber¹

¹Institut für Angewandte Physik, Universität Tübingen, ²Institut Max von Laue - Paul Langevin (ILL), ³Institut de Biologie Structurale, Université Grenoble Alpes, ⁴Institut Européen de Chimie et Biologie, Bordeaux INP, Chimie et Biologie des Membranes et des Nanoobjets (CBMN), Université de Bordeaux

Summary

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Neutron Spectroscopy

Picosecond nanosecond Dynamics

Proteins

Hydration Water

Neutron Backscattering

Molecular Dynamics

Neurodegenerative Diseases

Alzheimer s

Parkinson s

Energy Studies

Sample Holder Preparation

Indium Wire Seal

Hydrogen deuterium Exchange

Hydration Level

Chapters in this video

0:04

Introduction

1:04

Preparation of H₂O‐Hydrated Powders of Perdeuterated Protein

3:14

Incoherent Neutron Scattering Experiment

6:57

Results: Dynamics of Proteins and Hydration Water

7:57

Conclusion

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