Establishment of Murine Full‐Thickness Cartilage Defects Model
2:27
Measurement of Mechanical Withdrawal Threshold
3:12
Results: Comparative Analysis of Mechanical Withdrawal Threshold in Murine Models
4:10
Conclusion
Transcript
What this protocol not only mimics the occurrence and development of clinical FTCD, but also provides a reliable animal model for evaluating therapeutic treatments against FTCD. But this technique is easy to perform and enables growth observation
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This protocol establishes a full-thickness cartilage defects (FTCD) model by drilling holes in the femoral trochlear groove of rats and measuring the subsequent pain behavior and histopathological changes.