To comprehensively understand the various facet of thyroid hormone involvement in the central nervous system, we investigated spectrum of perspectives, spanning the hair phenotype to molecular adulation at the single-cell level. We are also looking on connecting those different dimension of the vibration to elucidate the mechanism of thyroid hormone in brain development. The mainstream research in the field primarily centers around the molecular biology with numerous researches investigating the impact of thyroid hormone on gene expression.
Nowadays, the increasing focus on behavior analysis to uncover the role of thyroid hormones, particularly within the central nervous system. This approach could explain the specific behaviors observed in certain thyroid hormone-related diseases. With the current level of available techniques, such as the rotarod test, researchers often struggle does this behavioral patterns, especially motor performance, in motor mice.
This hinders the translation of reside to clinical situations. Our protocol has been designed to assess several motor alteration in mice, facilitating a clear interpretation of behavior observations.
