Chapter 21
Drugs for Peptic Ulcer Disease
消化性溃疡病的病理生理学：伤害因素
Peptic ulcers are sores in the mucosa of the stomach or duodenum.
The mucosal epithelium houses acid-secreting parietal and gastrin-secreting G cells.
The ...
消化性溃疡病的病理生理学：粘膜防御因素
Peptic ulcer disease, or PUD, involves discontinuous gastrointestinal tract lining due to gastric acid or pepsin secretion.
The mucus-bicarbonate barrier ...
消化性溃疡的抑酸药物：质子泵抑制剂
Two of the main contributors to peptic ulcer formation are H. pylori infections or NSAID use, both facilitating gastric acid production.
Gastric acid is ...
消化性溃疡的抑酸药：组胺 H_2 受体拮抗剂
Histamine H2 receptors are G protein-coupled receptors located on the basolateral membrane of parietal cells.
Histamine released from ECL cells binds to ...
治疗消化性溃疡的抑酸药：抗酸药
In the gastric lumen, increased acid secretion can form or exacerbate ulcers in the mucosal layer.
Carbonate antacids, like sodium bicarbonate and calcium ...
治疗消化性溃疡的药物：硫酸铝作为粘膜保护剂
Recall that increased acid secretion in the gastric lumen disrupts mucosal defense mechanisms and weakens the mucus-bicarbonate barrier.
This enables ...
治疗消化性溃疡的药物：前列腺素类似物作为粘膜保护剂
The gastric mucosa majorly produces prostaglandin E2 and I2 to protect cells from mucosal injury.
These bind to EP3 receptors, which couple with ...
治疗消化性溃疡中的幽门螺杆菌：抗菌疗法
Helicobacter pylori or H. pylori, a gram-negative bacillus, thrives in the stomach's acidic environment, impairing somatostatin production. This ...
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