Chapter 21
Drugs for Peptic Ulcer Disease
Fisiopatologia da úlcera péptica: fatores lesivos
Peptic ulcers are sores in the mucosa of the stomach or duodenum.
The mucosal epithelium houses acid-secreting parietal and gastrin-secreting G cells.
The ...
Fisiopatologia da úlcera péptica: fatores de defesa da mucosa
Peptic ulcer disease, or PUD, involves discontinuous gastrointestinal tract lining due to gastric acid or pepsin secretion.
The mucus-bicarbonate barrier ...
Drogas supressoras de ácido para úlcera péptica: inibidores da bomba de prótons
Two of the main contributors to peptic ulcer formation are H. pylori infections or NSAID use, both facilitating gastric acid production.
Gastric acid is ...
Drogas supressoras de ácido para úlcera péptica: antagonistas do receptor H2 da histamina
Histamine H2 receptors are G protein-coupled receptors located on the basolateral membrane of parietal cells.
Histamine released from ECL cells binds to ...
Drogas supressoras de ácido para úlcera péptica: antiácidos
In the gastric lumen, increased acid secretion can form or exacerbate ulcers in the mucosal layer.
Carbonate antacids, like sodium bicarbonate and calcium ...
Medicamentos para úlcera péptica: Sucralfato como agentes protetores da mucosa
Recall that increased acid secretion in the gastric lumen disrupts mucosal defense mechanisms and weakens the mucus-bicarbonate barrier.
This enables ...
Medicamentos para úlcera péptica: análogos de prostaglandinas como agentes protetores da mucosa
The gastric mucosa majorly produces prostaglandin E2 and I2 to protect cells from mucosal injury.
These bind to EP3 receptors, which couple with ...
Tratamento de Helicobacter pylori em úlceras pépticas: terapia antimicrobiana
Helicobacter pylori or H. pylori, a gram-negative bacillus, thrives in the stomach's acidic environment, impairing somatostatin production. This ...
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