Chapter 21
Drugs for Peptic Ulcer Disease
Fisiopatología de la úlcera péptica: factores perjudiciales
Peptic ulcers are sores in the mucosa of the stomach or duodenum.
The mucosal epithelium houses acid-secreting parietal and gastrin-secreting G cells.
The ...
Fisiopatología de la úlcera péptica: factores de defensa de la mucosa
Peptic ulcer disease, or PUD, involves discontinuous gastrointestinal tract lining due to gastric acid or pepsin secretion.
The mucus-bicarbonate barrier ...
Fármacos supresores de ácido para la úlcera péptica: inhibidores de la bomba de protones
Two of the main contributors to peptic ulcer formation are H. pylori infections or NSAID use, both facilitating gastric acid production.
Gastric acid is ...
Fármacos supresores de ácido para la úlcera péptica: antagonistas de los receptores H2 de histamina
Histamine H2 receptors are G protein-coupled receptors located on the basolateral membrane of parietal cells.
Histamine released from ECL cells binds to ...
Fármacos supresores de ácido para la úlcera péptica: antiácidos
In the gastric lumen, increased acid secretion can form or exacerbate ulcers in the mucosal layer.
Carbonate antacids, like sodium bicarbonate and calcium ...
Fármacos para la úlcera péptica: sucralfato como agentes protectores de la mucosa
Recall that increased acid secretion in the gastric lumen disrupts mucosal defense mechanisms and weakens the mucus-bicarbonate barrier.
This enables ...
Fármacos para la úlcera péptica: análogos de las prostaglandinas como agentes protectores de la mucosa
The gastric mucosa majorly produces prostaglandin E2 and I2 to protect cells from mucosal injury.
These bind to EP3 receptors, which couple with ...
Tratamiento de Helicobacter pylori en úlceras pépticas: terapia antimicrobiana
Helicobacter pylori or H. pylori, a gram-negative bacillus, thrives in the stomach's acidic environment, impairing somatostatin production. This ...
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