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JoVE Journal

Neuroscience

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Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis

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06:07 min

May 6th, 2021

May 6th, 2021

5,596 Views

0:04

Introduction

0:56

Equipment Set-up and Animal Preparation

2:08

Photo-Thrombosis Surgery

3:48

Results: Analysis of the Mice After Photothrombotic Surgery

5:30

Conclusion

副本

The photothrombosis stroke model approach may by suitable for cellular and molecular studies of cortical plasticity because of the limited borders and flexibility to induce injury in different areas of the cortex. Three principle advantages distin

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Described here is the photothrombotic stroke model, where a stroke is produced through the intact skull by inducing permanent microvascular occlusion using laser illumination after administration of a photosensitive dye.

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