ai_agent

这项研究由成都中医药大学附属妇科资助。

本研究所有程序均通过临床试验注册进行，并经成都中医药大学附属医院伦理机构批准（备案号:2022SL-015）。本研究中的所有患者都获得了充分的知情同意，并同意研究人员在试验期间使用数据、图像和相关视频拍摄。2023年1月至2023年4月，在成都中医药大学医院住院部通过传单、文字交流、医生推荐等方式招募符合条件的患者。
1. 患者选择
<ol><li>纳入标准<ol><li>确认宫内妊娠。参考美国内科医师学会 2018年 10 月发布的《NVP 诊断和管理指南》，确定早孕呕吐为主要主诉，并确保参与者符合临床 NVP 的诊断标准。</li>
		<li>确认参与者目前没有参加其他临床试验。</li>
	</ol></li>
	<li>排除标准<ol><li>排除患有引起 NVP 的其他病理状况的个体，例如妊娠剧吐、妊娠相关性病毒性肝炎或妊娠相关性急性胃肠炎。</li>
		<li>排除拒绝接受耳膏治疗的参与者。</li>
		<li>排除患有严重 NVP 或对药物或其赋形剂过敏的个体以及耳廓损伤的参与者。</li>
		<li>排除在过去 2 周内接受过 NVP 治疗的患者。</li>
	</ol></li>
	<li>辍学个案的处理<ol><li>如果参与者无法维持对治疗的依从性，则退出试验。如果参与者选择退出研究，允许他们自愿退出研究。</li>
	</ol></li>
	<li>终止试验的标准<ol><li>终止在研究期间出现严重并发症或出现疾病进展的参与者。如果参与者出现严重的不良反应，则停止试验。</li>
	</ol></li>
</ol>2. 患者分组和治疗方案
<ol><li>招募20名患者，并将他们随机分配到实验组或对照组。</li>
	<li>为对照组提供控制饮食并进行常规治疗，包括补液和补充维生素（详见结果部分）。</li>
	<li>对于实验组，除常规治疗外，还进行耳膏治疗。</li>
	<li>确保两组的休息管理保持不变，直到患者出院。</li>
</ol>3. 耳膏治疗程序的准备
<ol><li>收集必要的物品（图1）:剪刀，无菌棉签，镊子，医用胶带，75%酒精和牛草种子（见 材料表）。</li>
	<li>耳膏的准备<ol><li>将胶带切成 0.6 厘米 x 0.6 厘米的正方形。</li>
		<li>取 1 或 2 颗光滑的牛草种子（B. Wang 的种子，从制药公司获得，见 材料表），并将它们放在每个胶带正方形的中心，如图 2 所示。</li>
	</ol></li>
	<li>患者准备<ol><li>指导患者以舒适的姿势坐下。</li>
		<li>检查耳朵皮肤的状况。 注意: 在进行治疗之前，请确保耳朵皮肤完好无损且没有任何异常（例如炎症、溃疡、冻伤等）。不应在耳廓创伤或炎症区域进行耳膏治疗。只有在这些异常消退且创伤愈合后才能进行。如果患者对胶带过敏，请使用替代材料。</li>
	</ol></li>
	<li>穴位的选择<ol><li>定位耳朵上的穴位/敏感区域。用一只手的拇指和食指向上捏住和抬起耳螺旋，使该区域完全暴露，从而稳定耳廓。</li>
		<li>另一只手拿着无菌拭子，轻轻探查患者的耳朵，以确定胃（CO4）、贲门（CO3）、腹部（AH8）、神门（TF4）、皮层下（AT4）和肝脏（CO12）六个耳廓点附近的敏感压力点（图3）。 注意: 敏感点是指在施加压力时与其他区域相比有明显酸痛、麻木、肿胀或疼痛的区域。与其他常见的耳穴相比，这些敏感穴位显示出更好的治疗效果7。根据先前的临床研究，六个耳穴点（CO4、CO3、AH8、TF4、AT4 和 CO12）通常用于治疗 NVP，并具有突出的止吐和镇静作用11,12,13。如果未检测到耳朵上的敏感点，则可以选择上述六个点进行后续治疗。</li>
	</ol></li>
	<li>消毒<ol><li>使用浸有酒精的棉球对操作员的手进行消毒。</li>
		<li>使用蘸有 75% 酒精的无菌棉签对患者的耳廓进行消毒。 注意: 消毒区域应覆盖目标点周围约 1-2 平方厘米的耳廓皮肤。酒精有助于去除皮肤表面的油脂，确保胶带具有更好的粘合性能。如果患者对酒精过敏，可以使用碘伏作为替代药物。</li>
	</ol></li>
</ol>4. 耳膏治疗
<ol><li>一旦该区域干燥，用一只手的拇指和食指捏住耳螺旋，将其向后和向上抬起，以稳定耳廓。</li>
	<li>使用镊子，取出准备好的耳膏（步骤3.2），将牛草的中心种子放在选定的点上， 如图4所示。与患者确认种子放置对应于敏感点或疼痛区域。</li>
	<li>将拇指和食指放在耳廓的前后，以有节奏的按压和放松运动施加适度且可忍受的压力，以刺激耳廓部位的牛草种子。在每个部位按下并松开3-5分钟，保持均匀的节奏。 注意: 根据与患者的沟通调整压力强度，确保在不过度用力的情况下感觉到酸痛、麻木、肿胀和疼痛。</li>
	<li>治疗后监测患者的整体状况 15 分钟。 注意: 如果出现恐慌、胸部不适、头晕或大量出汗，请立即撕下胶带。</li>
	<li>指导患者或其家属每天揉搓种子三次:早上、中午和晚上。 注意:强调当患者感到恶心时需要对种子进行额外刺激。</li>
	<li>三天后取下耳膏，在对侧耳朵上重复上述步骤，在两只耳朵之间交替治疗。 注意:继续治疗，直到患者符合出院标准:PUQE 评分 ≤4 且尿酮体变为阴性。如果耳膏脱落，请重新涂抹。</li>
</ol>5. 患者诊断
<ol><li>从住院第一天开始，每 2 天收集一次新鲜尿液，以测量和记录尿酮水平。注意从治疗开始到尿酮水平转为阴性的持续时间。 注:尿酮水平是评估NVP患者的重要指标。尿酮水平阳性表明持续饥饿和脱水14,15。确保及时检测尿液样本，防止酮体蒸发引起的低值。</li>
	<li>指导患者每天完成妊娠特有的呕吐和恶心量化 （PUQE） 量表（见 表 1）。每天根据他们的实际症状记录分数，直到出院当天。 注意:PUQE 量表广泛用于全球各种实践指南中，以测量患者 NVP 症状的严重程度16.PUQE 分数越高表示病情越严重。</li>
</ol>6. 术后护理
<ol><li>建议患者保持耳朵清洁和干燥。 注意: 种子贴片的放置不会干扰日常活动，例如洗涤和沐浴。</li>
	<li>提供安慰和支持，以减轻患者的紧张和恐惧。</li>
	<li>指导患者在出现恶心和呕吐时进行吞咽动作或深呼吸。</li>
	<li>如果患者在治疗过程中出现局部过敏反应，例如皮肤瘙痒、发红或渗出，请立即撕下胶带并局部涂抹抗过敏软膏以缓解这些症状。</li>
	<li>如果发生感染，应将其作为普通感染进行管理。使用外用抗生素（适用于孕妇）或消炎镇痛软膏进行治疗。</li>
	<li>监测呕吐的频率和量，评估脱水体征，并定期测量尿酮水平。 注意:如果存在影响胎儿发育和母体安全且无法有效解决的情况，请考虑终止妊娠。</li>
</ol>

用耳石膏治疗妊娠呕吐

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<li>Wu, S. S., Gao, X., Shi, Z. X. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Effect+of+pressured+beans+on+vomiting+and+sleep+in+lung+cancer+patients+undergoing+chemotherapy%5BTitle%5D)+AND+%22World+Latest+Medicine+Information%22%5BJournal%5D)">Effect of pressured beans on vomiting and sleep in lung cancer patients undergoing chemotherapy.</a> World Latest Medicine Information. 18 (24), 154-155 (2018).</li>
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</ol>

作者声明他们没有利益冲突。

妊娠期恶心和呕吐 （NVP） 是一种常见的疾病，可能对孕妇的健康构成风险，甚至会导致终止妊娠的并发症。通常用于止吐/抗恶心作用的临床药物，如昂丹司琼和异丙嗪，对孕妇有潜在风险，包括肌张力障碍、镇静和降低癫痫发作阈值22.因此，药物治疗有其自身的一系列危险。另一方面，今天通常采用的以症状为中心的治疗方法缺乏特异性，有时无效23.因此，?...

妊娠期恶心和呕吐 （NVP） 很常见，不同程度地影响约 50%-80% 的孕妇1。当NVP进展到中度或重度水平时，它会增加母亲和胎儿不良妊娠结局的风险。因此，NVP 的早期干预可能有助于预防妊娠剧吐2 的发生。NVP 的确切原因在现代生物医学中尚不清楚，但据信它与怀孕期间人绒毛膜促性腺激素血清水平的变化和某些维生素3 的缺乏等因素有关。目前 NVP 的治疗方法包括禁食、输液和纠正电解质失衡，但这些方法都不被认为是可靠的4。因此，找到一种不影响胚胎或胎儿发育的有效治疗方法是一项重大的临床挑战。
耳膏疗法是一种传统的中医治疗方法，涉及使用小而圆的物体，通常是牛草的种子，刺激耳朵上的特定穴位，以预防和治疗疾病5.牛痘的干燥和成熟种子，也称为牛草，用于这种疗法，因为它们被认为可以调节血液和通道，增强血液循环，促进泌乳。耳廓（耳朵的外侧）富含神经，包含许多针灸和敏感穴位6。通过刺激这些穴位，耳朵的软组织可能产生局部无菌炎症，进而可能调节神经内分泌系统，包括垂体-肾上腺皮质和交感神经-肾上腺皮质腺。此外，这种疗法可以潜在地激活人体的非特异性免疫反应，从而产生治疗效果7.耳膏疗法通过靶向耳朵上主要调节自主神经功能障碍、减少胃肠道反应和减轻呕吐感的特定穴位来有效治疗 NVP。它还可以增加Motilin的水平，Motilin是一种促进肠道蠕动的激素8，并恢复孕妇的食欲。此外，以前的一些研究表明，耳膏疗法可能对 NVP 相关的情绪障碍产生有利影响9，因为它在缓解焦虑方面表现出与镇静剂相似的作用。
耳膏疗法是一种简单且易于管理的治疗方法。它可以与常规治疗结合使用，以缓解NVP的症状，同时将母亲和胎儿与药物使用相关的潜在风险降至最低。该协议提供了有关如何进行这种治疗以及在此过程中要考虑的事项的详细说明。我们希望耳膏治疗能够得到更多的关注，并在临床实践中得到推广和利用。

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ear plaster therapy as a safe and effective treatment for gestational vomiting

妊娠期恶心和呕吐 （NVP） 是常见症状，通常使许多女性的妊娠早期复杂化。虽然禁食、输液和营养支持等临床治疗通常用于管理 NVP，但其有效性各不相同。然而，传统的耳膏疗法提供了一种很有前途的替代方案，可以有效缓解症状，并且对胚胎或胎儿的发育没有已知的风险。这种疗法以其易于应用、成本效益和良好的结果而闻名。先前的研究表明，将耳膏疗法与常规治疗相结合在缓解孕妇恶心和呕吐症状方面的有效性超过了单独使用常规治疗所取得的结果。本文介绍的方案描述了一种使用应用于特定耳点的圆形、光滑和坚硬的牛草种子来缓解NVP的方法。利用穴位按摩的原理，将这些种子轻轻擦到耳朵表面。通过刺激指定的耳穴，该程序旨在调节身体的能量流动并恢复平衡，从而降低NVP的严重程度和频率。将牛草种子涂抹在特定的耳穴上是一种简单的技术，医疗保健专业人员可以在适当的指导下轻松实施或由孕妇自行管理。总体而言，耳膏疗法提供了一种安全、有效和经济的方法来控制妊娠呕吐，为女性提供了一种潜在的解决方案，以减轻怀孕期间的不适。

这项临床研究的所有 20 名参与者都成功完成了试验。4例患者符合出院标准，第5天出院，其余16例患者符合出院标准，住院后2周内出院。
试验期间，对照组接受控制饮食和静脉滴注，包括以下成分:维生素C 2g+0.9%氯化钠注射液500 mL、维生素B6 0.2 g+0.9%氯化钠注射液500 mL、甲萘醌钾镁20 mL+5%葡萄糖注射液500 mL、氯化钾15 mL+葡萄糖注射液500 mL、0.9%氯化钠注射液500 mL、 和维生素 B1 200 ...

Watch this Scientific Journal Video about Alleviating Nausea and Vomiting in Pregnancy with Safe and Effective Auricular Acupuncture at JoVE.com

作者聚焦:通过安全有效的耳针缓解怀孕期间的恶心和呕吐 

所提出的方案描述了一种传统的中医治疗程序，以其在管理妊娠呕吐方面的安全性和有效性而闻名。

耳膏疗法是一种安全有效的妊娠呕吐治疗方法

Nausea and vomiting in pregnancy (NVP) are common symptoms that often complicate early pregnancy for many women. While clinical treatments such as ...

我们的研究重点是开发治疗怀孕期间恶心和呕吐的有效方法。我们的目标是探索在不影响胎儿发育的情况下最好地缓解此类患者症状的方法。治疗妊娠呕吐的最新进展包括许多药物，如维生素 B6、多西拉明和某种抗胆碱能药。此外，一些心理支持已被证明对康复很重要。耳膏治疗简单、经济、安全，在临床实践中被患者高度接受。这种疗法与传统的对症治疗相辅相成，在缓解孕妇呕吐和恶心症状方面更有效。我们的研究证明了我们的眼针治疗妊娠呕吐的有效性和安全性。现在需要更多的随机对照研究和临床试验来评估其疗效和副作用风险。

ear-plaster-therapy-as-safe-effective-treatment-for-gestational

Research

Education

JoVE Journal

JoVE Core

Pharmacology

Medicine

Ear Plaster Therapy as a Safe and Effective Treatment for Gestational Vomiting

Unit 1

Drugs for Nausea and Vomiting

SCIENTISTS IN ACTION

1.9K 次观看.  Hospital of Chengdu University of Traditional Chinese Medicine. 我们的研究重点是开发治疗怀孕期间恶心和呕吐的有效方法。我们的目标是探索在不影响胎儿发育的情况下最好地缓解此类患者症状的方法。治疗妊娠呕吐的最新进展包括许多药物，如维生素 B6、多西拉明和某种抗胆碱能药。此外，一些心理支持已被证明对康复很重要。耳膏治疗简单、经济、安全，在临床实践中被患者高度接受。这种疗法与传统的对症治疗相辅相成，?...

视频: 作者聚焦:通过安全有效的耳针缓解怀孕期间的恶心和呕吐 

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

The human placenta is highly inaccessible for research while still in utero. The current understanding of human placental physiology in vivo is therefore largely based on animal studies, despite the high diversity among species in placental anatomy, hemodynamics and duration of the pregnancy. The vast majority of human placenta studies are ex vivo perfusion studies or in vitro trophoblast studies. Although in vitro studies and animal models are essential, extrapolation of the results from such studies to the human placenta in vivo is uncertain. We aimed to study human placenta physiology in vivo at term, and present a detailed protocol of the method. Exploiting the intraabdominal access to the uterine vein just before the uterine incision during planned cesarean section, we collect blood samples from the incoming and outgoing vessels on the maternal and fetal sides of the placenta. When combining concentration measurements from blood samples with volume blood flow measurements, we are able to quantify placental and fetal uptake and release of any compound. Furthermore, placental tissue samples from the same mother-fetus pairs can provide measurements of transporter density and activity and other aspects of placental functions in vivo. Through this integrative use of the 4-vessel sampling method we are able to test some of the current concepts of placental nutrient transfer and metabolism in vivo, both in normal and pathological pregnancies. Furthermore, this method enables the identification of substances secreted by the placenta to the maternal circulation, which could be an important contribution to the search for biomarkers of placenta dysfunction.

体内人体胎盘生理学综合研究的 4 血管采样方法

We present a detailed method to study human placental physiology in vivo at term. The method combines blood sampling from the incoming and outgoing vessels on the maternal and fetal sides of the placenta with ultrasound measurements of volume blood flow and placental tissue sampling.

人体胎盘生理学综合研究的4血管取样方法体内

The human placenta is highly inaccessible for research while still in utero. The current understanding of human placental physiology in vivo is therefore ...

科研

医学

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

No effective treatments currently exist for placenta-associated pregnancy complications, and developing strategies for the targeted delivery of drugs to the placenta while minimizing fetal and maternal side effects remains challenging. Targeted nanoparticle carriers provide new opportunities to treat placental disorders. We recently demonstrated that a synthetic placental chondroitin sulfate A binding peptide (plCSA-BP) could be used to guide nanoparticles to deliver drugs to the placenta. In this protocol, we describe in detail a system for assessing the efficiency of drug delivery to the placenta by plCSA-BP that employs three separate methods used in combination: in vivo imaging, high-frequency ultrasound (HFUS), and high-performance liquid chromatography (HPLC). Using in vivo imaging, plCSA-BP-guided nanoparticles were visualized in the placentas of live animals, while HFUS and HPLC demonstrated that plCSA-BP-conjugated nanoparticles efficiently and specifically delivered methotrexate to the placenta. Thus, a combination of these methods can be used as an effective tool for the targeted delivery of drugs to the placenta and development of new treatment strategies for several pregnancy complications.

使用三种互补方法综合评价胎盘靶向药物递送的有效性和安全性

We describe a system that utilizes three methods to evaluate the safety and effectiveness of placenta-targeted drug delivery: in vivo imaging to monitor nanoparticle accumulation, high-frequency ultrasound to monitor placental and fetal development, and HPLC to quantify drug delivery to tissue.

用三种互补方法综合评价胎盘靶向药物的有效性和安全性

No effective treatments currently exist for placenta-associated pregnancy complications, and developing strategies for the targeted delivery of drugs to ...

生物工程

External Cephalic Version: Is it an Effective and Safe Procedure?

External cephalic version (ECV) is an effective procedure for reducing the number of cesarean sections. To date, there is no video publication showing the methodology of this procedure. The main objective is to show how to perform ECV with a specific protocol with tocolysis before the procedure and analgesia. Moreover, we describe and analyze the factors associated with successful ECV, and also compare to deliveries in the general pregnant population.
A retrospective and descriptive analysis of ECV carried out at the Hospital Clinico Universitario Virgen de la Arrixaca in Murcia (Spain) between 1/1/2014 and 12/31/2018 was assessed. The latest data available of labor deliveries in the local center, which is the biggest maternity department in Spain, were from 2018.
320 patients were recruited and 3 pregnant women were lost during the study. ECV was carried out at 37&#177;3 weeks gestation. ECV was successful in 82.5% (N=264). 19 complications were reported (5.9%): 8 vaginal bleeding (2.5%), 9 fetal bradycardia (2.8%), 1 preterm rupture of membranes (0.3%) and 1 cord prolapse (0.3%). A previous vaginal delivery increases the success rate of ECV ORadjusted=3.03 (1.62-5.68). Maternal Body Mass Index (BMI) affects the success of ECV ORadjusted=0.94 (0.89-0.99). Patients with BMI&#62;40 kg/m2 have an ORadjusted=0.09 (0.009-0.89) compared with those with BMI &#60;25 kg/m2. If ECV was successful, the cesarean delivery index is 22.2% (17.5-27.6%), the eutocic delivery index is 52.1% (46.1-58.1%) and the instrumented vaginal delivery index is 25.7% (20.7-31.2%). There are no differences in cesarean and eutocic delivery indexes after successful ECV. However, a successful ECV is associated with a 6.29% increase in the instrumented delivery rate (OR=1.63).
ECV is an effective procedure to reduce the number of cesarean sections for breech presentations. Maternal BMI and previous vaginal delivery are associated with ECV success. Successful ECV does not modify the usual delivery pattern.

胎头外倒转术：这是一种有效且安全的手术吗？

This article shows how to perform the external cephalic version (ECV) by two experienced obstetricians in the obstetric operating room in the presence of an anesthesiologist and a midwife. The ECV is carried out with analgesia and tocolysis. Two attempts are made under ultrasonography control.

外部脑积水版本:它是一个有效和安全的程序吗？

External cephalic version (ECV) is an effective procedure for reducing the number of cesarean sections. To date, there is no video publication showing the ...

Virtual Prism Adaptation Therapy: Protocol for Validation in Healthy Adults

Hemispatial neglect is a common impairment after stroke. It is associated with poor functional and social outcomes. Therefore, an adequate intervention is imperative for the successful management of hemispatial neglect. However, the clinical use of various interventions is limited in real clinical practice. Prism adaptation therapy is one of the most evidence-based rehabilitation modalities to treat hemispatial neglect. To overcome any possible shortcoming that may occur with prism therapy, we developed a new system using immersive virtual reality and depth-sensing camera to create a virtual prism adaptation therapy (VPAT). To validate the VPAT system, we designed an experimental protocol investigating the behavioral errors and changes in cortical activation via the VPAT system. Cortical activation was measured by functional near infrared spectroscopy (fNIRS). The experiment consisted of four phases. All four included clicking, pointing or rest applied to right-handed healthy people. Clicking versus pointing was used for investigating the cortical region related with the gross motor task, and pointing with VPAT versus pointing without VPAT was used for investigating the cortical region associated with visuospatial perception. The preliminary results from four healthy participants showed that pointing errors by the VPAT system was similar to the conventional prism adaptation therapy. Further analysis with more participants and fNIRS data, as well as a study in patients with stroke may be required.

虚拟棱镜适应疗法：健康成人验证方案

This experimental protocol demonstrates the use of virtual prism adaptation therapy (VPAT) in healthy adults and the association between VPAT and functional near infrared spectroscopy to determine the effect of VPAT on cortical activation. Results suggest that VPAT may be feasible and could induce similar behavioral adaptation as conventional prism adaptation therapy.

虚拟棱镜适应疗法:健康成人验证协议

Hemispatial neglect is a common impairment after stroke. It is associated with poor functional and social outcomes. Therefore, an adequate intervention is ...

Mouse In Vivo Placental Targeted CRISPR Manipulation

The placenta is an essential organ that regulates and maintains mammalian development in utero. The placenta is responsible for the transfer of nutrients and waste between the mother and fetus and the production and delivery of growth factors and hormones. Placental genetic manipulations in mice are critical for understanding the placenta's specific role in prenatal development. Placental-specific Cre-expressing transgenic mice have varying effectiveness, and other methods for placental gene manipulation can be useful alternatives. This paper describes a technique to directly alter placental gene expression using CRISPR gene manipulation, which can be used to modify the expression of targeted genes. Using a relatively advanced surgical approach, pregnant dams undergo a laparotomy on embryonic day 12.5 (E12.5), and a CRISPR plasmid is delivered by a glass micropipette into the individual placentas. The plasmid is immediately electroporated after each injection. After dam recovery, the placentas and embryos can continue development until assessment at a later time point. The evaluation of the placenta and offspring after the use of this technique can determine the role of time-specific placental function in development. This type of manipulation will allow for a better understanding of how placental genetics and function impact fetal growth and development in multiple disease contexts.

小鼠体内胎盘靶向 CRISPR作

Here we describe a time-specific method to effectively manipulate critical developmental pathways in the mouse placenta in vivo. This is performed through the injection and electroporation of CRISPR plasmids into the placentas of pregnant dams on embryonic day 12.5.

小鼠 体内 胎盘靶向CRISPR操作

The placenta is an essential organ that regulates and maintains mammalian development in utero. The placenta is responsible for the transfer of nutrients ...

遗传学

<meta charset="utf8"></head><body>穴位和耳石膏疗法治疗 AECOPD 患者睡眠障碍

Acupoint Application Combined with Ear Plaster Therapy for Treating Sleep Disorders with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease (COPD) is a lung disease characterized by persistent airflow limitation, which is not fully reversible and progressive. Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) refers to acute changes in respiratory distress, cough, and sputum in COPD patients at baseline levels. Sleep disorders are a very common complication in patients with AECOPD. At present, long-term use of sedative-hypnotics alone has many side effects, such as mental and physical dependence and cognitive impairment. While the efficacy of other special intervention methods is not clear, and the cost is high, there is an urgent need for effective and safe treatment in clinics. Acupoint application and ear plaster therapy are considered the characteristic therapies of traditional Chinese medicine. They have the advantages of small side effects, high safety, and simple procedure. This study will elucidate in detail the specific process and efficacy of the two treatment methods for AECOPD complicated with sleep disorders, including medical devices used, selection of acupoints, procedure, and posttreatment care. This study is intended to provide a new reference for the clinical treatment modality of this type of disease.

<meta charset="utf8"></head><body>作者聚焦:治疗急性慢性阻塞性肺病睡眠障碍的中医 — 一种安全、经济高效的方法

The present protocol describes the specific process and efficacy of the acupoint application combined with ear plaster therapy for sleep disorders in a patient with acute exacerbation of chronic obstructive pulmonary disease, including medical devices, selection of acupoints, operating methods, and posttreatment care.

穴位应用联合耳石膏治疗慢性阻塞性肺疾病急性加重的睡眠障碍

Chronic Obstructive Pulmonary Disease (COPD) is a lung disease characterized by persistent airflow limitation, which is not fully reversible and ...

加强 CINV 管理:传统中医方法

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting

Chemotherapy-induced nausea and vomiting (CINV) refers to the nausea and vomiting experienced by patients after the application of chemotherapy drugs, significantly affecting their quality of life and physical recovery, as well as increasing the pain of the patients. Basic medicine primarily focuses on acid suppression, gastric protection, and vomiting suppression, but there are still many patients with nausea and vomiting symptoms that cannot be alleviated. Traditional Chinese medicine (TCM) can effectively alleviate nausea and vomiting through acupoint stimulation and pressure, while also offering advantages such as simplicity, affordability, and fewer side effects. The aim of this article is to introduce the method of using acupoint application combined with acupressure as an adjunctive therapy for CINV, using the Multinational Association of Supportive Care in Cancer (MASCC) Antiemesis Tool (MAT) tablet scale as a questionnaire. The article details aspects such as acupoint selection, production, and the use of acupoint application, massage techniques, and operating procedures, all with the goal of ensuring the safety and efficacy of acupoint application combined with acupressure as an adjuvant therapy, thereby improving patients&#39; clinical symptoms and quality of life.

作者聚焦: 使用穴位应用和穴位按压对化疗引起的恶心和呕吐进行有效的非药物管理

Acupoint application combined with acupressure-assisted treatment has a good effect on chemotherapy-induced nausea and vomiting and is more convenient and cost-effective.

穴位应用联合穴位按压作为化疗引起的恶心呕吐的辅助治疗

Chemotherapy-induced nausea and vomiting (CINV) refers to the nausea and vomiting experienced by patients after the application of chemotherapy drugs, ...

<meta charset="utf8"></head><body>局部热疗有效的疣治疗:一种微创方法

Local Hyperthermia for Warts Treatment

Warts, benign epidermal proliferations, are a direct result of human papillomavirus (HPV) infection, specifically targeting the keratinocytes within the stratum corneum of the skin. The development of warts is the most common clinical manifestation of HPV, with plantar warts, condylomata acuminata, and common warts being the most frequently observed types. These growths can be unsightly and sometimes painful, affecting the quality of life for those afflicted. Although various treatments are available, ranging from topical medications to surgical procedures, the quest for a treatment that is both safe and effective while minimizing invasiveness continues. This is particularly crucial for populations with heightened risk factors, such as immuno-compromised individuals. In the clinical need for minimally invasive treatments, local hyperthermia has emerged as a promising therapeutic strategy for wart management. As demonstrated in various studies, local hyperthermia is effective as a standalone treatment, offering a valuable alternative for patients seeking less intrusive therapeutic options.

<meta charset="utf8"></head><body>作者聚焦:皮肤病理学和性传播疾病的治疗

Here, we present a protocol for local hyperthermia, a new and effective therapeutic for treating warts. We also showcase its safety and efficacy as an independent treatment.

局部热疗治疗疣

Warts, benign epidermal proliferations, are a direct result of human papillomavirus (HPV) infection, specifically targeting the keratinocytes within the ...

行为学

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy

Endoscopic vacuum therapy (EVT) offers an effective alternative for the treatment of anastomotic leakage. Current treatment options for leakage include conservative treatment, stent placement, or reoperation. However, conservative treatment often results in slow recovery and is frequently ineffective in severe cases. Stent placement carries risks such as migration or blockage, and both conservative treatment and stents often fail to adequately drain pus or necrotic tissue exudate. Moreover, reoperation is associated with a high risk of surgical complications. EVT employs continuous negative pressure to remove pus and necrotic tissue exudate through natural orifices. This approach also promotes granulation tissue formation at the fistula or leakage site, facilitating the healing process. Clinically, EVT has demonstrated the potential to significantly reduce complications such as infection, bleeding, and anastomotic stenosis. It not only improves patient&#39;s outcomes but also minimizes the need for additional invasive procedures and shortens hospital stays. In conclusion, EVT represents a promising and innovative approach for managing complex gastrointestinal leaks.

Here, we present a protocol for endoscopic vacuum therapy (EVT) in the management of anastomotic leaks following total gastrectomy with esophagojejunostomy.

内窥镜真空疗法治疗食管空肠吻合术全胃切除术后吻合口漏

Endoscopic vacuum therapy (EVT) offers an effective alternative for the treatment of anastomotic leakage. Current treatment options for leakage include ...

Osteopathic Manipulative Treatment as a Useful Adjunctive Tool for Pneumonia

Pneumonia, the inflammatory state of lung tissue primarily due to microbial infection, claimed 52,306 lives in the United States in 20071 and resulted in the hospitalization of 1.1 million patients2. With an average length of in-patient hospital stay of five days2, pneumonia and influenza comprise significant financial burden costing the United States $40.2 billion in 20053. Under the current Infectious Disease Society of America/American Thoracic Society guidelines, standard-of-care recommendations include the rapid administration of an appropriate antibiotic regiment, fluid replacement, and ventilation (if necessary). Non-standard therapies include the use of corticosteroids and statins; however, these therapies lack conclusive supporting evidence4. (Figure 1)

Osteopathic Manipulative Treatment (OMT) is a cost-effective adjunctive treatment of pneumonia that has been shown to reduce patients&#8217; length of hospital stay, duration of intravenous antibiotics, and incidence of respiratory failure or death when compared to subjects who received conventional care alone5. The use of manual manipulation techniques for pneumonia was first recorded as early as the Spanish influenza pandemic of 1918, when patients treated with standard medical care had an estimated mortality rate of 33%, compared to a 10% mortality rate in patients treated by osteopathic physicians6. When applied to the management of pneumonia, manual manipulation techniques bolster lymphatic flow, respiratory function, and immunological defense by targeting anatomical structures involved in the these systems7,8, 9, 10.

The objective of this review video-article is three-fold: a) summarize the findings of randomized controlled studies on the efficacy of OMT in adult patients with diagnosed pneumonia, b) demonstrate established protocols utilized by osteopathic physicians treating pneumonia, c) elucidate the physiological mechanisms behind manual manipulation of the respiratory and lymphatic systems. Specifically, we will discuss and demonstrate four routine techniques that address autonomics, lymph drainage, and rib cage mobility: 1) Rib Raising, 2) Thoracic Pump, 3) Doming of the Thoracic Diaphragm, and 4) Muscle Energy for Rib 1.5,11

整骨手法治疗作为肺炎的有用辅助工具

Pneumonia is one of the top ten leading causes of death in the U.S. Osteopathic manipulative techniques (OMT) may be utilized as an adjunctive therapy in the treatment of pneumonia to enhance biomechanical and immune function; and ultimately, to reduce hospital stay, duration of antibiotics, incidence of respiratory failure, and mortality. In this video-article, we will review randomized controlled studies on the use of OMT in pneumonia patients, as well as demonstrate specific hands-on techniques that are routinely practiced by osteopathic physicians when treating pulmonary infections.

整骨手法治疗为肺炎是非常好的辅助工具

Pneumonia, the inflammatory state of lung tissue primarily due to microbial infection, claimed 52,306 lives in the United States in 20071 and resulted in ...

耳膏疗法是一种安全有效的妊娠呕吐治疗方法

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整骨手法治疗为肺炎是非常好的辅助工具

耳膏疗法是一种安全有效的妊娠呕吐治疗方法

Transcript

Summary

Explore More Videos

人体胎盘生理学综合研究的4血管取样方法体内

用三种互补方法综合评价胎盘靶向药物的有效性和安全性

外部脑积水版本:它是一个有效和安全的程序吗？

虚拟棱镜适应疗法:健康成人验证协议

小鼠 体内 胎盘靶向CRISPR操作

穴位应用联合耳石膏治疗慢性阻塞性肺疾病急性加重的睡眠障碍

穴位应用联合穴位按压作为化疗引起的恶心呕吐的辅助治疗

局部热疗治疗疣

内窥镜真空疗法治疗食管空肠吻合术全胃切除术后吻合口漏

整骨手法治疗为肺炎是非常好的辅助工具

小鼠体内胎盘靶向CRISPR操作