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JoVE Journal

Medicine

This content is Open Access.

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

16.9K Views

12:21 min

November 26th, 2015

November 26th, 2015

16,855 Views

0:05

Title

2:10

Surgical Preparation and Positioning

5:09

Surgical Procedure

8:07

Round Window Application of Ototoxic Agent

9:52

Results: Targeted Cochlear Damage After Heptanol Exposure

11:18

Conclusion

Various methods exist for introducing ototoxic agents to the cochleae of animal models. Presented is a surgical protocol for delivery of ototoxic agents to the round window niche. The procedure is reliable, creates targeted intra-cochlear lesions, and avoids mechanical damage to the microarchitecture. Examination of cochlear self-repair/regeneration is possible.

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