Name: wheelcon: a wheel control-based gaming platform for studying human sensorimotor control
Uploaded: 2020-08-15T13:00:00
Description: Watch this Scientific Journal Video about WheelCon: A Wheel Control-Based Gaming Platform for Studying Human Sensorimotor Control at JoVE.com

We thank Mr. Zhengyang Wang for reshaping the scripts, shooting and editing the video, and Mr. Ziyuan Ye for editing the video. This study got support from CIT Endowment &#38; National Science Foundation (to JCD),&#160;Boswell fellowship (to QL) and High-level University Fund (No. G02386301, G02386401), Guangdong Natural Science Foundation Joint Fund (No. 2019A1515111038).&#160;

The development and application of the protocol were approved by the California Institute of Technology Institutional Review Board (IRB) and the Southern University of Science and Technology IRB. The subject provided informed consent prior to any procedures being performed.
1. System preparation and setup
<ol>
	<li>The recommended basic hardware is a&#160;2 GHz dual-core processor and 4 GB of system memory.</li>
	<li>Build the gaming platform under the Unity platform, while using C# programi...

<ol>
	<li>Franklin, D. W., Wolpert, D. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Computational+Mechanisms+of+Sensorimotor+Control.">Computational Mechanisms of Sensorimotor Control.</a> Neuron. 72 (3), 425-442 (2011).</li><li>Bays, P. M., Wolpert, D. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Computational+principles+of+sensorimotor+control+that+minimize+uncertainty+and+variability.">Computational principles of sensorimotor control that minimize uncertainty and variability.</a> The Journal of Physiology. 578 (2), 387-396 (2007).</li><li>Desmurget, M., Grafton, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Forward+modeling+allows+feedback+control+for+fast+reaching+movements.">Forward modeling allows feedback control for fast reaching movements.</a> Trends in Cognitive Sciences. 4 (11), 423-431 (2000).</li><li>Sanger, T. D., Merzenich, M. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Computational+Model+of+the+Role+of+Sensory+Disorganization+in+Focal+Task-Specific+Dystonia.">Computational Model of the Role of Sensory Disorganization in Focal Task-Specific Dystonia.</a> Journal of Neurophysiology. 84 (5), 2458-2464 (2000).</li><li>Mohler, H., Okada, T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Benzodiazepine+receptor:+demonstration+in+the+central+nervous+system.">Benzodiazepine receptor: demonstration in the central nervous system.</a> Science. 198 (4319), 849-851 (1977).</li><li>Muller, L., Chavane, F., Reynolds, J., Sejnowski, T. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Cortical+travelling+waves:+mechanisms+and+computational+principles.">Cortical travelling waves: mechanisms and computational principles.</a> Nature Reviews Neuroscience. 19 (5), 255-268 (2018).</li><li>Zhang, H., Watrous, A. J., Patel, A., Jacobs, J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Theta+and+Alpha+Oscillations+Are+Traveling+Waves+in+the+Human+Neocortex.">Theta and Alpha Oscillations Are Traveling Waves in the Human Neocortex.</a> Neuron. 98 (6), 1269-1281 (2018).</li><li>Blinks, J. R., R&#252;del, R., Taylor, S. R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Calcium+transients+in+isolated+amphibian+skeletal+muscle+fibres:+detection+with+aequorin.">Calcium transients in isolated amphibian skeletal muscle fibres: detection with aequorin.</a> The Journal of Physiology. 277 (1), 291-323 (1978).</li><li>Gallivan, J. P., Chapman, C. S., Wolpert, D. M., Flanagan, J. R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Decision-making+in+sensorimotor+control.">Decision-making in sensorimotor control.</a> Nature Reviews Neuroscience. 19 (9), 519-534 (2018).</li><li>Sanger, T. D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Basic+and+Translational+Neuroscience+of+Childhood-Onset+Dystonia:+A+Control-Theory+Perspective.">Basic and Translational Neuroscience of Childhood-Onset Dystonia: A Control-Theory Perspective.</a> Annual Review of Neuroscience. 41 (1), 41-59 (2018).</li><li>Todorov, E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Optimality+principles+in+sensorimotor+control.">Optimality principles in sensorimotor control.</a> Nature Neuroscience. 7 (9), 907-915 (2004).</li><li>Todorov, E., Jordan, M. I. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Optimal+feedback+control+as+a+theory+of+motor+coordination.">Optimal feedback control as a theory of motor coordination.</a> Nature Neuroscience. 5 (11), 1226-1235 (2002).</li><li>Wolpert, D. M., Flanagan, J. R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Computations+underlying+sensorimotor+learning.">Computations underlying sensorimotor learning.</a> Current Opinion in Neurobiology. 37, 7-11 (2016).</li><li>Kiper, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Computational+models+and+motor+learning+paradigms:+Could+they+provide+insights+for+neuroplasticity+after+stroke?+An+overview.">Computational models and motor learning paradigms: Could they provide insights for neuroplasticity after stroke? An overview.</a> Journal of the Neurological Sciences. 369, 141-148 (2016).</li><li>Cluff, T., Crevecoeur, F., Scott, S. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Tradeoffs+in+optimal+control+capture+patterns+of+human+sensorimotor+control+and+adaptation.">Tradeoffs in optimal control capture patterns of human sensorimotor control and adaptation.</a> bioRxiv. , 730713 (2019).</li><li>Nakahira, Y., Liu, Q., Bernat, N., Sejnowski, T., Doyle, J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Theoretical+foundations+for+layered+architectures+and+speed-accuracy+tradeoffs+in+sensorimotor+control.">Theoretical foundations for layered architectures and speed-accuracy tradeoffs in sensorimotor control.</a> 2019 American Control Conference (ACC). , 809-814 (2019).</li><li>K&#246;rding, K. P., Wolpert, D. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Bayesian+integration+in+sensorimotor+learning.">Bayesian integration in sensorimotor learning.</a> Nature. 427 (6971), 244-247 (2004).</li><li>Chambers, C., Sokhey, T., Gaebler-Spira, D., Kording, K. P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+development+of+Bayesian+integration+in+sensorimotor+estimation.">The development of Bayesian integration in sensorimotor estimation.</a> Journal of Vision. 18 (12), 8 (2018).</li><li>Karmali, F., Whitman, G. T., Lewis, R. F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Bayesian+optimal+adaptation+explains+age-related+human+sensorimotor+changes.">Bayesian optimal adaptation explains age-related human sensorimotor changes.</a> Journal of Neurophysiology. 119 (2), 509-520 (2017).</li><li>Gori, J., Rioul, O. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Information-Theoretic+Analysis+of+the+Speed-Accuracy+Tradeoff+with+Feedback.">Information-Theoretic Analysis of the Speed-Accuracy Tradeoff with Feedback.</a> 2018 IEEE International Conference on Systems, Man, and Cybernetics (SMC). , 3452-3457 (2018).</li><li>Trendafilov, D., Polani, D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Information-theoretic+Sensorimotor+Foundations+of+Fitts'+Law.">Information-theoretic Sensorimotor Foundations of Fitts' Law.</a> Extended Abstracts of the 2019 CHI Conference on Human Factors in Computing Systems. , 1-6 (2019).</li><li>Fitts, P. M., Peterson, J. R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Information+capacity+of+discrete+motor+responses.">Information capacity of discrete motor responses.</a> Journal of Experimental Psychology. 67 (2), 103-112 (1964).</li><li>Fitts, P. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+information+capacity+of+the+human+motor+system+in+controlling+the+amplitude+of+movement.">The information capacity of the human motor system in controlling the amplitude of movement.</a> Journal of Experimental Psychology. 47 (6), 381-391 (1954).</li><li>Nakahira, Y., Matni, N., Doyle, J. C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Hard+limits+on+robust+control+over+delayed+and+quantized+communication+channels+with+applications+to+sensorimotor+control.">Hard limits on robust control over delayed and quantized communication channels with applications to sensorimotor control.</a> 2015 54th IEEE Conference on Decision and Control (CDC). , 7522-7529 (2015).</li><li>. Neural Correlates of Sensorimotor Control in Human Cortex: State Estimates and Reference Frames Available from: <a target="_blank" href="https://resolver.caltech.edu/CaltechTHESIS:05302019-163325527">https://resolver.caltech.edu/CaltechTHESIS:05302019-163325527</a> (2019)</li><li>Miall, R. C., Wolpert, D. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Forward+Models+for+Physiological+Motor+Control.">Forward Models for Physiological Motor Control.</a> Neural Networks. 9 (8), 1265-1279 (1996).</li><li>Battaglia-Mayer, A., Caminiti, R., Lacquaniti, F., Zago, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Multiple+Levels+of+Representation+of+Reaching+in+the+Parieto-frontal+Network.">Multiple Levels of Representation of Reaching in the Parieto-frontal Network.</a> Cerebral Cortex. 13 (10), 1009-1022 (2003).</li><li>Scott, S. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Optimal+feedback+control+and+the+neural+basis+of+volitional+motor+control.">Optimal feedback control and the neural basis of volitional motor control.</a> Nature Reviews Neuroscience. 5 (7), 532-545 (2004).</li><li>Saunders, J. A., Knill, D. C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Humans+use+continuous+visual+feedback+from+the+hand+to+control+fast+reaching+movements.">Humans use continuous visual feedback from the hand to control fast reaching movements.</a> Experimental Brain Research. 152 (3), 341-352 (2003).</li><li>Insperger, T., Milton, J., St&#233;p&#225;n, G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Acceleration+feedback+improves+balancing+against+reflex+delay.">Acceleration feedback improves balancing against reflex delay.</a> Journal of The Royal Society Interface. 10 (79), 20120763 (2013).</li><li>Birbaumer, N. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Breaking+the+silence:+Brain-computer+interfaces+(BCI)+for+communication+and+motor+control.">Breaking the silence: Brain-computer interfaces (BCI) for communication and motor control.</a> Psychophysiology. 43 (6), 517-532 (2006).</li><li>Liu, Q., Farahibozorg, S., Porcaro, C., Wenderoth, N., Mantini, D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Detecting+large-scale+networks+in+the+human+brain+using+high-density+electroencephalography.">Detecting large-scale networks in the human brain using high-density electroencephalography.</a> Human Brain Mapping. 38 (9), 4631-4643 (2017).</li><li>Nicolelis, M. A. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Brain-machine+interfaces+to+restore+motor+function+and+probe+neural+circuits.">Brain-machine interfaces to restore motor function and probe neural circuits.</a> Nature Reviews Neuroscience. 4 (5), 417-422 (2003).</li><li>Nordin, A. D., Hairston, W. D., Ferris, D. P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Faster+Gait+Speeds+Reduce+Alpha+and+Beta+EEG+Spectral+Power+From+Human+Sensorimotor+Cortex.">Faster Gait Speeds Reduce Alpha and Beta EEG Spectral Power From Human Sensorimotor Cortex.</a> IEEE Transactions on Biomedical Engineering. 67 (3), 842-853 (2020).</li><li>Hallett, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Transcranial+magnetic+stimulation+and+the+human+brain.">Transcranial magnetic stimulation and the human brain.</a> Nature. 406 (6792), 147-150 (2000).</li><li>Madhavan, S., Weber, K. A., Stinear, J. W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Non-invasive+brain+stimulation+enhances+fine+motor+control+of+the+hemiparetic+ankle:+implications+for+rehabilitation.">Non-invasive brain stimulation enhances fine motor control of the hemiparetic ankle: implications for rehabilitation.</a> Experimental Brain Research. 209 (1), 9-17 (2011).</li><li>Denoyelle, N., Pouget, F., Vi&#233;ville, T., Alexandre, F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=.">.</a> VirtualEnaction: A Platform for Systemic Neuroscience Simulation. , (2014).</li><li>Butti, N., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Virtual+Reality+Social+Prediction+Improvement+and+Rehabilitation+Intensive+Training+(VR-SPIRIT)+for+paediatric+patients+with+congenital+cerebellar+diseases:+study+protocol+of+a+randomised+controlled+trial.">Virtual Reality Social Prediction Improvement and Rehabilitation Intensive Training (VR-SPIRIT) for paediatric patients with congenital cerebellar diseases: study protocol of a randomised controlled trial.</a> Trials. 21 (1), 82 (2020).</li><li>McCall, J. V., Ludovice, M. C., Blaylock, J. A., Kamper, D. G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+Platform+for+Rehabilitation+of+Finger+Individuation+in+Children+with+Hemiplegic+Cerebral+Palsy.">A Platform for Rehabilitation of Finger Individuation in Children with Hemiplegic Cerebral Palsy.</a> 2019 IEEE 16th International Conference on Rehabilitation Robotics (ICORR). , 343-348 (2019).</li><li>Demers, M., Levin, M. F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Kinematic+Validity+of+Reaching+in+a+2D+Virtual+Environment+for+Arm+Rehabilitation+After+Stroke.">Kinematic Validity of Reaching in a 2D Virtual Environment for Arm Rehabilitation After Stroke.</a> IEEE Transactions on Neural Systems and Rehabilitation Engineering. 28 (3), 679-686 (2020).</li><li>Zbytniewska, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Design+and+Characterization+of+a+Robotic+Device+for+the+Assessment+of+Hand+Proprioceptive,+Motor,+and+Sensorimotor+Impairments.">Design and Characterization of a Robotic Device for the Assessment of Hand Proprioceptive, Motor, and Sensorimotor Impairments.</a> 2019 IEEE 16th International Conference on Rehabilitation Robotics (ICORR). , 441-446 (2019).</li><li>Delp, S. L., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=OpenSim:+Open-Source+Software+to+Create+and+Analyze+Dynamic+Simulations+of+Movement.">OpenSim: Open-Source Software to Create and Analyze Dynamic Simulations of Movement.</a> IEEE Transactions on Biomedical Engineering. 54 (11), 1940-1950 (2007).</li><li>Gray, W. D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Plateaus+and+Asymptotes:+Spurious+and+Real+Limits+in+Human+Performance.">Plateaus and Asymptotes: Spurious and Real Limits in Human Performance.</a> Current Directions in Psychological Science. 26 (1), 59-67 (2017).</li></ol>

In this paper, we have presented a free, open-source gaming platform, WheelCon, for studying the effects of delay, quantization, disturbance, and layered feedback loops in human sensorimotor control. We have shown the hardware, the software, and the GUI. The settings of a single sensorimotor control loop with delay and quantization have been implemented, which allows us to measure the effects of delay, quantization, and disturbance in sensorimotor control. The experimental results are well in line with the prediction fro...

The human sensorimotor control system is extremely robust1, although the sensing is distributed, variable, sparse, quantized, noisy and delayed2,3,4; the computing in the central nervous system is slow5,6,7; and the muscle actuation fatigues and saturates8. Many computational theoretical models have been proposed to explain the complicated human sensorimotor control process4,9,10,11,12,13,14, which is a tradeoff process in human reach and response15,16. For example, feedback control theory predicts the optimal control policy12, Bayesian theory models sensorimotor learning17,18,19 and information theory sensorimotor foundation20,21. In contrast to the abundance of theoretical models, experimental platforms capable of manipulating important components of multiple feedback loops lack development. This is in part due to the fact that designing a platform to bridge and test these aspects of sensorimotor control requires a diverse range of expertise, extending from motor control theory, signal processing, and interaction, all the way to computer graphics and programming. Researchers often develop their own custom hardware/software systems to characterize human sensorimotor control performance, which can limit the ability to compare/contrast and integrate datasets across research groups. The development of an easy-to-use and validated system could broaden the quantitative characterization of sensorimotor control.
In this paper, we present the WheelCon platform, a novel, free and open-source platform to design video games for a virtual environment that noninvasively simulates a Fitts&#8217; Law reaching game and a mountain bike task with downing a steep, twisting and bumpy trail. The Fitts&#8217; law for reaching task quantifies the tradeoff between speed and accuracy in which the time required for reaching a target of width at distance scales as22,23. The &#39;mountain-bike task&#39; is a combination of a pursuit and compensatory tracking task, which are two classic components of research on human sensorimotor performance, especially in terms of studying feedback loops.
WheelCon contains the highly demanded basic components presented in each theory: delay, quantization, noise, disturbance, and multiple feedback loops. It is a potential tool for studying the following diverse questions in human sensorimotor control:
&#8226; How the human sensorimotor system deals with the delay and quantization in neural signaling, which is fundamentally constrained by the limited resources (such as the space and metabolic costs) in the brain24,25; &#8226; How neural correlation in the human cortex with sensorimotor control26; &#8226; How humans handle the unpredictable, external disturbances in sensorimotor control27; &#8226; How the hierarchical control loops layered and integrated within human sensorimotor system16,28,29; &#8226; The consequence of the delay and quantization in human visual feedback30 and reflex feedback31 in sensorimotor control; &#8226; The optimal policy and strategy for sensorimotor learning under delay and quantization16,17,24,29.
WheelCon integrates with a steering wheel and can simulate game conditions that manipulate the variables in these questions, such as signaling delay, quantization, noise, and disturbance, while recording the dynamic control policy and system errors. It also allows researchers to study the layered architecture in sensorimotor control. In the example of riding a mountain bike, two control layers are involved in this task: the high-layer plan and the low-layer reflex. For visible disturbances (i.e., the trail), we plan before the disturbance arrives. For disturbances unknown in advance (i.e., small bumps), the control relies on delayed reflexes. Feedback control theory proposes that effective layered architectures can integrate the higher layers&#39; goals, plans, decisions with the lower layers&#39; sensing, reflex, and action24. WheelCon provides experimental tools to induce distinctive disturbances in the plan and reflex layers separately for testing such a layered architecture (Figure 1).
We provide a cheap, easy to use and flexible to program platform, WheelCon that bridges the gap between theoretical and experimental studies on neuroscience. To be specific, it can be used for examining the effects of delay, quantization, disturbance, potentially speed-accuracy tradeoffs. The variables that can be manipulated in control loops are shown in Table 1. It can also be applied for studying decision making and multiplexing ability across different control layers in human sensorimotor control. Moreover, WheelCon is compatible with noninvasive neural recordings, such as electroencephalography (EEG), to measure the neural response during sensorimotor control32,33,34,35, and the non-invasive brain stimulation techniques, such as Transcranial Electrical Stimulation (tES) and Transcranial Magnetic Stimulation (TMS), to manipulate the neural activity36,37.

<table>
	<tbody>
		<tr>
			<td>Gaming Wheel</td>
			<td>Logitech</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Windows 10 OS</td>
			<td>Microsoft</td>
			<td></td>
			<td></td>
		</tr>
	</tbody>
</table>

wheelcon: a wheel control-based gaming platform for studying human sensorimotor control

Feedback control theory has been extensively implemented to theoretically model human sensorimotor control. However, experimental platforms capable of manipulating important components of multiple feedback loops lack development. This paper describes WheelCon, an open-source platform aimed at resolving such insufficiencies. Using only a computer, a standard display, and inexpensive gaming steering wheel equipped with a force feedback motor, WheelCon safely simulates the canonical sensorimotor task of riding a mountain bike down a steep, twisting, bumpy trail. The platform provides flexibility, as will be demonstrated in the demos provided, so that researchers may manipulate the disturbances, delay, and quantization (data rate) in the layered feedback loops, including a high-level advanced plan layer and a low-level delayed reflex layer. In this paper, we illustrate WheelCon&#39;s graphical user interface (GUI), the input and output of existing demos, and how to design new games. In addition, we present the basic feedback model and the experimental results from the demo games, which align well with the model&#39;s prediction. The WheelCon platform can be downloaded at https://github.com/Doyle-Lab/WheelCon. In short, the platform is featured to be cheap, simple to use, and flexible to program for effective sensorimotor neuroscience research and control engineering education.

Modelling Feedback Control
We show a simplified feedback control model shown in Figure 1. The system dynamics is given by:
<img alt="Equation 1" src="/files/ftp_upload/61092/61092equ01.jpg" />
where x(t) is the error at time t, r(t) is the trail disturbance w(t), is the bump disturbance, and u(...

Watch this Scientific Journal Video about WheelCon: A Wheel Control-Based Gaming Platform for Studying Human Sensorimotor Control at JoVE.com

WheelCon: A Wheel Control-Based Gaming Platform for Studying Human Sensorimotor Control

WheelCon is a novel, free and open-source platform to design video games that noninvasively simulates mountain biking down a steep, twisting, bumpy trail. It contains components presenting in human sensorimotor control (delay, quantization, noise, disturbance, and multiple feedback loops) and allows researchers to study the layered architecture in sensorimotor control.

Feedback control theory has been extensively implemented to theoretically model human sensorimotor control. However, experimental platforms capable of ...

Human sensory motor control system is extremely robust, although the sensing is distributed, sparse, quantized, noisy, and delayed. The computing in the central nervous system is slow, the muscle actuation fatigues and saturates. To study this causal factors and its consequence on the system performance of sensory motor control, it is important to develop an easy-to-use experimental platform which manipulate these factors and record the performance.Here we presents a gaming platform called the WheelCon, which is a free and open source platform to design video games for our virtual environment that simulates riding a mountain bike down a steep, twisted, bumpy trail. WheelCon integrates with a steering wheel as it can manipulate the variables in the human sensory motor control system, such as signaling delay, quantization, noise, and the disturbance while recording the motor control trajectory and aerodynamics. It also allows research to study the layer the architects in sensory motor control, including the higher layer's goals, plans, decisions, and the lower layer's sensing, reflex and action.On the computer running Windows 10, go to the WheelCon webpage, click Clone or download, then click Download ZIP in the popup dialog. Extract all the files to the local hard drive. Go to the manufacturer's website and download the corresponding driver for your racing wheel model.Mount the racing wheel securely at sitting level in front of a monitor. Connect the wheel's USB cable to the PC and the power adapter to an outlet. To test the program, double-click wheelcon.exe in the Excutable Output file's folder. Configure the settings according to monitor setup and click Play. Seat the subject down comfortably behind the wheels.Make sure the subject is allowed adequate range of motion when handling the wheel. Click Fitt's Law Task. Click on the text box and type a name for the output file, include subject and task information.Click Select File, then select Fitt's Law. txt as input. Click Begin Game.Instruct the subject to track the gray zone with the green line by turning the steering wheel. This game serves to familiarize the subject with the setup. Click Mountain Bike Task.Type the output file name and select Vision_Delay.txt. Click Begin Game to start testing. In this game, the length of the look-ahead window changes to provide advanced warning, no warning or a visual delay.Click Mountain Bike Task, type the output file name and select Action_Delay.txt. Click Begin Game to start testing. In this game, a delay is added between the subject's wheel turning and the green line's movement.The delay starts at zero seconds and increases by 0.15 seconds until it reaches 0.75 seconds. Click Mountain Bike Task, type the output file name and select Vision Quantization.txt. Click Begin Game to start testing.In this game, the visual data rate is manipulated. When visual data is low, the trail can only appear in a few loose gray locations. As the visual data rate increases, the gray zone can appear in more potential locations and its movement becomes more continuous.Click Mountain Bike Task, type the output file name and select Action Quantization.txt. Click Begin Game to start testing. In this game, action data rate is manipulated.When data rate is at its slowest, the gray line can only go at one speed. As data rate increases, controlling wheel speed becomes finer. Click Mountain Bike Task, type the output file name and select Bump Trail.txt.Click Begin Game to start testing. In this game, disturbances are added either as a torque on the wheel, simulating a bump, a sudden turn on the trail or the two types of disturbances combined. To retrieve test results go to the Executable Output file's folder, and look for the file with previously specified file names.From left to right, each row in the output file specifies time, trial position, bump size, action data rate, action delay, visual delay, visual data rate, tracking error, and steering wheel angle. To develop a new input file, open the WheelCon Mntn Bike Trail Design Code. m in the Source Code folder with Matlab.Selecting this section of the code for the desired game parameters, press Control plus T to uncomment, then press Run. The input file will be regenerated in the same folder. As the figure suggests, in games with either visual or action delays, the subject's error increased with bigger delays.Limiting data rates in either visual input or action output resulted in larger errors. This figure shows the aerodynamics during trials with either only bumps, only turns or the two combined. As you're watching this video, you should be familiar with how to apply WheelCon to a human sensory motor control study.

wheelcon-wheel-control-based-gaming-platform-for-studying-human

Research

JoVE Journal

Neuroscience

Measuring Circadian and Acute Light Responses in Mice using Wheel Running Activity

Circadian rhythms are physiological functions that cycle over a period of approximately 24 hours (circadian- circa: approximate and diem: day)1, 2. They are responsible for timing our sleep/wake cycles and hormone secretion. Since this timing is not precisely 24-hours, it is synchronized to the solar day by light input. This is accomplished via photic input from the retina to the suprachiasmatic nucleus (SCN) which serves as the master pacemaker synchronizing peripheral clocks in other regions of the brain and peripheral tissues to the environmental light dark cycle3-7. The alignment of rhythms to this environmental light dark cycle organizes particular physiological events to the correct temporal niche, which is crucial for survival8. For example, mice sleep during the day and are active at night. This ability to consolidate activity to either the light or dark portion of the day is referred to as circadian photoentrainment and requires light input to the circadian clock9. Activity of mice at night is robust particularly in the presence of a running wheel. Measuring this behavior is a minimally invasive method that can be used to evaluate the functionality of the circadian system as well as light input to this system. Methods that will covered here are used to examine the circadian clock, light input to this system, as well as the direct influence of light on wheel running behavior.

This article will review methods that can be used to determine circadian function and light responsiveness in mice.

Circadian rhythms are physiological functions that cycle over a period of approximately 24 hours (circadian- circa: approximate and diem: day)1, 2.  They ...

Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform

The vestibular organ is a sensor that measures angular and linear accelerations with six degrees of freedom (6DF). Complete or partial defects in the vestibular organ results in mild to severe equilibrium problems, such as vertigo, dizziness, oscillopsia, gait unsteadiness nausea and/or vomiting. A good and frequently used measure to quantify gaze stabilization is the gain, which is defined as the magnitude of compensatory eye movements with respect to imposed head movements. To test vestibular function more fully one has to realize that 3D VOR ideally generates compensatory ocular rotations not only with a magnitude (gain) equal and opposite to the head rotation but also about an axis that is co-linear with the head rotation axis (alignment). Abnormal vestibular function thus results in changes in gain and changes in alignment of the 3D VOR response.
Here we describe a method to measure 3D VOR using whole body rotation on a 6DF motion platform. Although the method also allows testing translation VOR responses 1, we limit ourselves to a discussion of the method to measure 3D angular VOR. In addition, we restrict ourselves here to description of data collected in healthy subjects in response to angular sinusoidal and impulse stimulation.
Subjects are sitting upright and receive whole-body small amplitude sinusoidal and constant acceleration impulses. Sinusoidal stimuli (f = 1 Hz, A = 4&deg;) were delivered about the vertical axis and about axes in the horizontal plane varying between roll and pitch at increments of 22.5&deg; in azimuth. Impulses were delivered in yaw, roll and pitch and in the vertical canal planes. Eye movements were measured using the scleral search coil technique 2. Search coil signals were sampled at a frequency of 1 kHz.
The input-output ratio (gain) and misalignment (co-linearity) of the 3D VOR were calculated from the eye coil signals 3.
Gain and co-linearity of 3D VOR depended on the orientation of the stimulus axis. Systematic deviations were found in particular during horizontal axis stimulation. In the light the eye rotation axis was properly aligned with the stimulus axis at orientations 0&deg; and 90&deg; azimuth, but gradually deviated more and more towards 45&deg; azimuth.
The systematic deviations in misalignment for intermediate axes can be explained by a low gain for torsion (X-axis or roll-axis rotation) and a high gain for vertical eye movements (Y-axis or pitch-axis rotation (see Figure 2). Because intermediate axis stimulation leads a compensatory response based on vector summation of the individual eye rotation components, the net response axis will deviate because the gain for X- and Y-axis are different.
In darkness the gain of all eye rotation components had lower values. The result was that the misalignment in darkness and for impulses had different peaks and troughs than in the light: its minimum value was reached for pitch axis stimulation and its maximum for roll axis stimulation.
Case Presentation
Nine subjects participated in the experiment. All subjects gave their informed consent. The experimental procedure was approved by the Medical Ethics Committee of Erasmus University Medical Center and adhered to the Declaration of Helsinki for research involving human subjects.
Six subjects served as controls. Three subjects had a unilateral vestibular impairment due to a vestibular schwannoma. The age of control subjects (six males and three females) ranged from 22 to 55 years. None of the controls had visual or vestibular complaints due to neurological, cardio vascular and ophthalmic disorders.
The age of the patients with schwannoma varied between 44 and 64 years (two males and one female). All schwannoma subjects were under medical surveillance and/or had received treatment by a multidisciplinary team consisting of an othorhinolaryngologist and a neurosurgeon of the Erasmus University Medical Center. Tested patients all had a right side vestibular schwannoma and underwent a wait and watch policy (Table 1; subjects N1-N3) after being diagnosed with vestibular schwannoma. Their tumors had been stabile for over 8-10 years on magnetic resonance imaging.

A method is described to measure three-dimensional vestibulo ocular reflexes (3D VOR) in humans using a six degrees of freedom (6DF) motion simulator. The gain and misalignment of the 3D angular VOR provide a direct measure of the quality of vestibular function. Representative data on healthy subjects are provided

The vestibular organ is a sensor that measures angular and linear accelerations with six degrees of freedom (6DF). Complete or partial defects in the ...

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents

When rodents have free access to a running wheel in their home cage, voluntary use of this wheel will depend on the time of day1-5. Nocturnal rodents, including rats, hamsters, and mice, are active during the night and relatively inactive during the day. Many other behavioral and physiological measures also exhibit daily rhythms, but in rodents, running-wheel activity serves as a particularly reliable and convenient measure of the output of the master circadian clock, the suprachiasmatic nucleus (SCN) of the hypothalamus. In general, through a process called entrainment, the daily pattern of running-wheel activity will naturally align with the environmental light-dark cycle (LD cycle; e.g. 12 hr-light:12 hr-dark). However circadian rhythms are endogenously generated patterns in behavior that exhibit a ~24 hr period, and persist in constant darkness. Thus, in the absence of an LD cycle, the recording and analysis of running-wheel activity can be used to determine the subjective time-of-day. Because these rhythms are directed by the circadian clock the subjective time-of-day is referred to as the circadian time (CT). In contrast, when an LD cycle is present, the time-of-day that is determined by the environmental LD cycle is called the zeitgeber time (ZT).
Although circadian rhythms in running-wheel activity are typically linked to the SCN clock6-8, circadian oscillators in many other regions of the brain and body9-14 could also be involved in the regulation of daily activity rhythms. For instance, daily rhythms in food-anticipatory activity do not require the SCN15,16 and instead, are correlated with changes in the activity of extra-SCN oscillators17-20. Thus, running-wheel activity recordings can provide important behavioral information not only about the output of the master SCN clock, but also on the activity of extra-SCN oscillators. Below we describe the equipment and methods used to record, analyze and display circadian locomotor activity rhythms in laboratory rodents.

Circadian rhythms in voluntary wheel-running activity in mammals are tightly coupled to the molecular oscillations of a master clock in the brain. As such, these daily rhythms in behavior can be used to study the influence of genetic, pharmacological, and environmental factors on the functioning of this circadian clock.

When rodents have free access to a running wheel in their home cage, voluntary use of this wheel will depend on the time of day1-5. Nocturnal rodents, ...

A Simplified Method for Ultra-Low Density, Long-Term Primary Hippocampal Neuron Culture

Culturing primary hippocampal neurons in vitro facilitates mechanistic interrogation of many aspects of neuronal development. Dissociated embryonic hippocampal neurons can often grow successfully on glass coverslips at high density under serum-free conditions, but low density cultures typically require a supply of trophic factors by co-culturing them with a glia feeder layer, preparation of which can be time-consuming and laborious. In addition, the presence of glia may confound interpretation of results and preclude studies on neuron-specific mechanisms. Here, a simplified method is presented for ultra-low density (~2,000 neurons/cm2), long-term (&#62;3 months) primary hippocampal neuron culture that is under serum free conditions and without glia cell support. Low density neurons are grown on poly-D-lysine coated coverslips, and flipped on high density neurons grown in a 24-well plate. Instead of using paraffin dots to create a space between the two neuronal layers, the experimenters can simply etch the plastic bottom of the well, on which the high density neurons reside, to create a microspace conducive to low density neuron growth. The co-culture can be easily maintained for &#62;3 months without significant loss of low density neurons, thus facilitating the morphological and physiological study of these neurons. To illustrate this successful culture condition, data are provided to show profuse synapse formation in low density cells after prolonged culture. This co-culture system also facilitates the survival of sparse individual neurons grown in islands of poly-D-lysine substrates and thus the formation of autaptic connections.

Low density cultures of primary hippocampal neurons usually require glia feeder layer to supply neurotrophic factors and sustain longevity. We describe here a simplified method to culture ultra-low density neurons on glass coverslips in the presence of a high density neuronal feeder layer, which facilitates investigation of specific neuronal-autonomous mechanisms.

Culturing primary hippocampal neurons in vitro facilitates mechanistic interrogation of many aspects of neuronal development. Dissociated embryonic ...

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications

Many attempts have been made to manufacture multi-contact nerve cuff electrodes that are safe, robust and reliable for long term neuroprosthetic applications. This protocol describes a fabrication technique of a modified cylindrical nerve cuff electrode to meet these criteria. Minimum computer-aided design and manufacturing (CAD and CAM) skills are necessary to consistently produce cuffs with high precision (contact placement 0.51 &#177; 0.04 mm) and various cuff sizes. The precision in spatially distributing the contacts and the ability to retain a predefined geometry accomplished with this design are two criteria essential to optimize the cuff&#39;s interface for selective recording and stimulation. The presented design also maximizes the flexibility in the longitudinal direction while maintaining sufficient rigidity in the transverse direction to reshape the nerve by using materials with different elasticities. The expansion of the cuff&#39;s cross sectional area as a result of increasing the pressure inside the cuff was observed to be 25% at 67 mm Hg. This test demonstrates the flexibility of the cuff and its response to nerve swelling post-implant. The stability of the contacts&#39; interface and recording quality were also examined with contacts&#39; impedance and signal-to-noise ratio metrics from a chronically implanted cuff (7.5 months), and observed to be 2.55 &#177; 0.25 k&#8486; and 5.10 &#177; 0.81 dB respectively.

This article provides a detailed description on the fabrication process of a high contact-density flat interface nerve electrode (FINE). This electrode is optimized for recording and stimulating neural activity selectively within peripheral nerves.

Many attempts have been made to manufacture multi-contact nerve cuff electrodes that are safe, robust and reliable for long term neuroprosthetic ...

&#181;Tongue: A Microfluidics-Based Functional Imaging Platform for the Tongue In Vivo

Intravital fluorescence microscopy is a tool used widely to study multicellular dynamics in a live animal. However, it has not been successfully used in the taste sensory organ. By integrating microfluidics into the intravital tongue imaging window, the &#181;Tongue provides reliable functional images of taste cells in vivo under controlled exposure to multiple tastants. In this paper, a detailed step-by-step procedure to utilize the &#181;Tongue system is presented. There are five subsections: preparing of tastant solutions, setting up of a microfluidic module, sample mounting, acquiring functional image data, and data analysis. Some tips and techniques to solve the practical issues that may arise when using the &#181;Tongue are also presented.

 &amp;#181;Tongue: A Microfluidics-Based Functional Imaging Platform for the Tongue In Vivo

The article introduces the &#181;Tongue (microfluidics-on-a-tongue) device for functional taste cell imaging in vivo by integrating microfluidics into an intravital imaging window on the tongue.

Intravital fluorescence microscopy is a tool used widely to study multicellular dynamics in a live animal. However, it has not been successfully used in ...

A Flexible Platform for Monitoring Cerebellum-Dependent Sensory Associative Learning

Climbing fiber inputs to Purkinje cells provide instructive signals critical for cerebellum-dependent associative learning. Studying these signals in head-fixed mice facilitates the use of imaging, electrophysiological, and optogenetic methods. Here, a low-cost behavioral platform (~$1000) was developed that allows tracking of associative learning in head-fixed mice that locomote freely on a running wheel. The platform incorporates two common associative learning paradigms: eyeblink conditioning and delayed tactile startle conditioning. Behavior is tracked using a camera and the wheel movement by a detector. We describe the components and setup and provide a detailed protocol for training and data analysis. This platform allows the incorporation of optogenetic stimulation and fluorescence imaging. The design allows a single host computer to control multiple platforms for training multiple animals simultaneously.

We have developed a single platform to track animal behavior during two climbing fiber-dependent associative learning tasks. The low-cost design allows integration with optogenetic or imaging experiments directed towards climbing fiber-associated cerebellar activity.

Climbing fiber inputs to Purkinje cells provide instructive signals critical for cerebellum-dependent associative learning. Studying these signals in ...

Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter TMS

Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning

Skilled motor ability depends on efficiently integrating sensory afference into the appropriate motor commands. Afferent inhibition provides a valuable tool to probe the procedural and declarative influence over sensorimotor integration during skilled motor actions. This manuscript describes the methodology and contributions of short-latency afferent inhibition (SAI) for understanding sensorimotor integration. SAI quantifies the effect of a convergent afferent volley on the corticospinal motor output evoked by transcranial magnetic stimulation (TMS). The afferent volley is triggered by the electrical stimulation of a peripheral nerve. The TMS stimulus is delivered to a location over the primary motor cortex that elicits a reliable motor-evoked response in a muscle served by that afferent nerve. The extent of inhibition in the motor-evoked response reflects the magnitude of the afferent volley converging on the motor cortex and involves central GABAergic and cholinergic contributions. The cholinergic involvement in SAI makes SAI a possible marker of declarative-procedural interactions in sensorimotor performance and learning. More recently, studies have begun manipulating the TMS current direction in SAI to tease apart the functional significance of distinct sensorimotor circuits in the primary motor cortex for skilled motor actions. The ability to control additional pulse parameters (e.g., the pulse width) with state-of-the-art controllable pulse parameter TMS (cTMS) has enhanced the selectivity of the sensorimotor circuits probed by the TMS stimulus and provided an opportunity to create more refined models of sensorimotor control and learning. Therefore, the current manuscript focuses on SAI assessment using cTMS. However, the principles outlined here also apply to SAI assessed using conventional fixed pulse width TMS stimulators and other forms of afferent inhibition, such as long-latency afferent inhibition (LAI).

Author Spotlight: Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning  

Short-latency afferent inhibition (SAI) is a transcranial magnetic stimulation protocol to probe sensorimotor integration. This article describes how SAI can be used to study the convergent sensorimotor loops in the motor cortex during sensorimotor behavior.

Skilled motor ability depends on efficiently integrating sensory afference into the appropriate motor commands. Afferent inhibition provides a valuable ...

A Setup for Human Vision, Cognition, and Interaction in Real-Life Scenarios

A Naturalistic Setup for Presenting Real People and Live Actions in Experimental Psychology and Cognitive Neuroscience Studies

Perception of others&#39; actions is crucial for survival, interaction, and communication. Despite decades of cognitive neuroscience research dedicated to understanding the perception of actions, we are still far away from developing a neurally inspired computer vision system that approaches human action perception. A major challenge is that actions in the real world consist of temporally unfolding events in space that happen &#34;here and now&#34; and are actable. In contrast, visual perception and cognitive neuroscience research to date have largely studied action perception through 2D displays (e.g., images or videos) that lack the presence of actors in space and time, hence these displays are limited in affording actability. Despite the growing body of knowledge in the field, these challenges must be overcome for a better understanding of the fundamental mechanisms of the perception of others&#39; actions in the real world. The aim of this study is to introduce a novel setup to conduct naturalistic laboratory experiments with live actors in scenarios that approximate real-world settings. The core element of the setup used in this study is a transparent organic light-emitting diode (OLED) screen through which participants can watch the live actions of a physically present actor while the timing of their presentation is precisely controlled. In this work, this setup was tested in a behavioral experiment. We believe that the setup will help researchers reveal fundamental and previously inaccessible cognitive and neural mechanisms of action perception and will be a foundation for future studies investigating social perception and cognition in naturalistic settings.

Author Spotlight: A Novel Setup to Conduct Naturalistic Laboratory Experiments with Real Human Actors in Scenarios 

This study presents a naturalistic experimental setup that allows researchers to present real-time action stimuli, obtain response time and mouse tracking data while participants respond after each stimulus display, and change actors between experimental conditions with a unique system including a special transparent organic light-emitting diode (OLED) screen and light manipulation.

Perception of others&#39; actions is crucial for survival, interaction, and communication. Despite decades of cognitive neuroscience research dedicated to ...