Results: Representative Mouse Lung Histologic and Morphometric Findings
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Conclusion
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The constant pressure within the fixation device maintains the lungs in a reasonably inflated state generating a histological lung specimen suitable for evaluating mild cigarette smoke induced emphysema. The main advantage of this model is that it
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Presented here is a useful protocol for lung fixation that creates a stable condition for histological evaluate of lung specimens from a mouse model of emphysema. The main advantage of this model is that it can fix many lungs with the same constant pressure without lung collapse or deflation.