Gordana Vunjak-Novakovic

Tissue engineering: the next generation.

Engineering cartilage and bone using human mesenchymal stem cells.

Silk fibroin microtubes for blood vessel engineering.

Characterization of electrical stimulation electrodes for cardiac tissue engineering.

Pre-treatment of synthetic elastomeric scaffolds by cardiac fibroblasts improves engineered heart tissue.

Effects of chondrogenic and osteogenic regulatory factors on composite constructs grown using human mesenchymal stem cells, silk scaffolds and bioreactors.

Engineering custom-designed osteochondral tissue grafts.

Cardiac tissue engineering using perfusion bioreactor systems.

Engineering of functional cartilage tissue using stem cells from synovial lining: a preliminary study.

Effects of electrical stimulation in C2C12 muscle constructs.

Effects of initial seeding density and fluid perfusion rate on formation of tissue-engineered bone.

Synovium-derived stem cell-based chondrogenesis.

Engineered microenvironments for controlled stem cell differentiation.

The effect of devitalized trabecular bone on the formation of osteochondral tissue-engineered constructs.

Gel spinning of silk tubes for tissue engineering.

Optical mapping of impulse propagation in engineered cardiac tissue.

Patterning stem cell differentiation.

Micro-bioreactor arrays for controlling cellular environments: design principles for human embryonic stem cell applications.

Engineered microenvironments for human stem cells.

Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering.

Tissue engineered bone grafts: biological requirements, tissue culture and clinical relevance.

Biomimetic approach to tissue engineering.

Electrical stimulation systems for cardiac tissue engineering.

Hypoxia and stem cell-based engineering of mesenchymal tissues.

A biocompatible endothelial cell delivery system for in vitro tissue engineering.

Percutaneous cell delivery into the heart using hydrogels polymerizing in situ.

Bone grafts engineered from human adipose-derived stem cells in perfusion bioreactor culture.

Challenges in cardiac tissue engineering.

Controllable expansion of primary cardiomyocytes by reversible immortalization.

Electrical stimulation of human embryonic stem cells: cardiac differentiation and the generation of reactive oxygen species.

Geometry and force control of cell function.

Engineering anatomically shaped human bone grafts.

Alignment and elongation of human adipose-derived stem cells in response to direct-current electrical stimulation.

Micropatterned three-dimensional hydrogel system to study human endothelial-mesenchymal stem cell interactions.

Perfusion seeding of channeled elastomeric scaffolds with myocytes and endothelial cells for cardiac tissue engineering.

Effects of hyperinsulinemia on lipolytic function of three-dimensional adipocyte/endothelial co-cultures.

Biodegradable fibrous scaffolds with tunable properties formed from photo-cross-linkable poly(glycerol sebacate).

Adipose tissue engineering for soft tissue regeneration.

Spatial regulation of human mesenchymal stem cell differentiation in engineered osteochondral constructs: effects of pre-differentiation, soluble factors and medium perfusion.

Surface-patterned electrode bioreactor for electrical stimulation.

Bone tissue engineering with human stem cells.

Geometric control of human stem cell morphology and differentiation.

Ingrowth of human mesenchymal stem cells into porous silk particle reinforced silk composite scaffolds: An in vitro study.

Silk hydrogel for cartilage tissue engineering.

Tissue engineering by self-assembly and bio-printing of living cells.

Bioactive scaffolds for engineering vascularized cardiac tissues.

Patterning osteogenesis by inducible gene expression in microfluidic culture systems.

Microfluidic device generating stable concentration gradients for long term cell culture: application to Wnt3a regulation of β-catenin signaling.

Scaffold stiffness affects the contractile function of three-dimensional engineered cardiac constructs.

Adipogenic differentiation of human adipose-derived stem cells on 3D silk scaffolds.

Adipose tissue as a stem cell source for musculoskeletal regeneration.

Tubular silk scaffolds for small diameter vascular grafts.

Lipolytic function of adipocyte/endothelial cocultures.

Nucleation and growth of mineralized bone matrix on silk-hydroxyapatite composite scaffolds.

Potential pathophysiological mechanisms in osteonecrosis of the jaw.

Biomimetic platforms for human stem cell research.

Bioreactor cultivation of functional bone grafts.

Optimizing the medium perfusion rate in bone tissue engineering bioreactors.

Composite scaffold provides a cell delivery platform for cardiovascular repair.

Bioengineering heart muscle: a paradigm for regenerative medicine.

Optimization of electrical stimulation parameters for cardiac tissue engineering.

Micropatterned mammalian cells exhibit phenotype-specific left-right asymmetry.

Derivation of two new human embryonic stem cell lines from nonviable human embryos.

Hybrid gel composed of native heart matrix and collagen induces cardiac differentiation of human embryonic stem cells without supplemental growth factors.

In vitro platforms for tissue engineering: implications for basic research and clinical translation.

Effects of pamidronate on human alveolar osteoblasts in vitro.

Optimizing dynamic interactions between a cardiac patch and inflammatory host cells.

Time-dependent processes in stem cell-based tissue engineering of articular cartilage.

Channelled scaffolds for engineering myocardium with mechanical stimulation.

Engineering tissue with BioMEMS.

In vitro model of vascularized bone: synergizing vascular development and osteogenesis.

Biomimetic perfusion and electrical stimulation applied in concert improved the assembly of engineered cardiac tissue.

Development of silk-based scaffolds for tissue engineering of bone from human adipose-derived stem cells.

Micropatterning chiral morphogenesis.

Vascular endothelial growth factor secretion by nonmyocytes modulates Connexin-43 levels in cardiac organoids.

Engineering bone tissue from human embryonic stem cells.

Biofabrication enables efficient interrogation and optimization of sequential culture of endothelial cells, fibroblasts and cardiomyocytes for formation of vascular cords in cardiac tissue engineering.

Bone scaffold architecture modulates the development of mineralized bone matrix by human embryonic stem cells.

Macrophages modulate the viability and growth of human mesenchymal stem cells.

Human adipose-derived cells can serve as a single-cell source for the in vitro cultivation of vascularized bone grafts.

The effect of controlled expression of VEGF by transduced myoblasts in a cardiac patch on vascularization in a mouse model of myocardial infarction.

Concise review: personalized human bone grafts for reconstructing head and face.

Transient hypoxia improves matrix properties in tissue engineered cartilage.

Microfluidic bioreactor for dynamic regulation of early mesodermal commitment in human pluripotent stem cells.

Sequential application of steady and pulsatile medium perfusion enhanced the formation of engineered bone.

Tissue engineering strategies for skeletal repair.

Assembly of complex cell microenvironments using geometrically docked hydrogel shapes.

Bioreactor engineering of stem cell environments.

Insulin, ascorbate, and glucose have a much greater influence than transferrin and selenous acid on the in vitro growth of engineered cartilage in chondrogenic media.

Cartilage constructs engineered from chondrocytes overexpressing IGF-I improve the repair of osteochondral defects in a rabbit model.

Noninvasive imaging of myocyte apoptosis following application of a stem cell-engineered delivery platform to acutely infarcted myocardium.

Supplementation of exogenous adenosine 5'-triphosphate enhances mechanical properties of 3D cell-agarose constructs for cartilage tissue engineering.

Engineering bone tissue substitutes from human induced pluripotent stem cells.

Micropatterning of cells reveals chiral morphogenesis.

Patterning pluripotency in embryonic stem cells.

Decellularization of human and porcine lung tissues for pulmonary tissue engineering.

Age-related carbonylation of fibrocartilage structural proteins drives tissue degenerative modification.

In vitro mesenchymal trilineage differentiation and extracellular matrix production by adipose and bone marrow derived adult equine multipotent stromal cells on a collagen scaffold.

Bioengineering heart tissue for in vitro testing.

The regulation of growth and metabolism of kidney stem cells with regional specificity using extracellular matrix derived from kidney.

Electrical stimulation via a biocompatible conductive polymer directs retinal progenitor cell differentiation.

Biomimetic electrical stimulation platform for neural differentiation of retinal progenitor cells.

Portable bioreactor for perfusion and electrical stimulation of engineered cardiac tissue.

Galvanic microparticles increase migration of human dermal fibroblasts in a wound-healing model via reactive oxygen species pathway.

Biomimetic scaffold combined with electrical stimulation and growth factor promotes tissue engineered cardiac development.

Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.

Electrically conductive chitosan/carbon scaffolds for cardiac tissue engineering.

Electrical stimulation enhances cell migration and integrative repair in the meniscus.

The current status of iPS cells in cardiac research and their potential for tissue engineering and regenerative medicine.

Physical influences on stem cells.

HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease.

The role of macrophage phenotype in vascularization of tissue engineering scaffolds.

Myocardial tissue engineering: in vitro models.

Microscale technologies for regulating human stem cell differentiation.

Bioengineered human tumor within a bone niche.

Large, stratified, and mechanically functional human cartilage grown in vitro by mesenchymal condensation.

Natural cardiac extracellular matrix hydrogels for cultivation of human stem cell-derived cardiomyocytes.

Silk microfiber-reinforced silk hydrogel composites for functional cartilage tissue repair.

Endothelial cells enhance the migration of bovine meniscus cells.

Macrophages modulate engineered human tissues for enhanced vascularization and healing.

Hierarchically ordered nanopatterns for spatial control of biomolecules.

Bupivacaine mandibular nerve block affects intraoperative blood pressure and heart rate in a Yucatan miniature swine mandibular condylectomy model: a pilot study.

Passage-dependent relationship between mesenchymal stem cell mobilization and chondrogenic potential.

Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds.

Nutrient channels and stirring enhanced the composition and stiffness of large cartilage constructs.

Matrix Production in Large Engineered Cartilage Constructs Is Enhanced by Nutrient Channels and Excess Media Supply.

Bioengineered tumors.

Synergistic effects of hypoxia and morphogenetic factors on early chondrogenic commitment of human embryonic stem cells in embryoid body culture.

Tissue-engineered models of human tumors for cancer research.

Clinical translation of controlled protein delivery systems for tissue engineering.

Engineering physiologically stiff and stratified human cartilage by fusing condensed mesenchymal stem cells.

Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation.

"The state of the heart": Recent advances in engineering human cardiac tissue from pluripotent stem cells.

Advanced methods for tissue engineering and regenerative medicine.

Bioengineering methods for myocardial regeneration.

Introducer Development for Coronary Sinus Access From Parasternal Mediastinotomy.

Challenges in engineering osteochondral tissue grafts with hierarchical structures.

Targeted delivery of liquid microvolumes into the lung.

Cardiac biology: A protein for healing infarcted hearts.

Controlled release of cytokines using silk-biomaterials for macrophage polarization.

Rapid retraction of microvolume aqueous plugs traveling in a wettable capillary.

Differential gene expression in human, murine, and cell line-derived macrophages upon polarization.

Heterogeneous engineered cartilage growth results from gradients of media-supplemented active TGF-β and is ameliorated by the alternative supplementation of latent TGF-β.

Tissue Engineering and Regenerative Medicine 2015: A Year in Review.

Tissue-Engineering for the Study of Cardiac Biomechanics.

Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes.

Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue.

Immune modulation as a therapeutic strategy in bone regeneration.

Should we use cells, biomaterials, or tissue engineering for cartilage regeneration?

Bioengineered Models of Solid Human Tumors for Cancer Research.

Modeling tumor microenvironments using custom-designed biomaterial scaffolds.

High seeding density of human chondrocytes in agarose produces tissue-engineered cartilage approaching native mechanical and biochemical properties.

Mesenchymal Stem Cells for Osteochondral Tissue Engineering.

Optimizing nutrient channel spacing and revisiting TGF-beta in large engineered cartilage constructs.

Recapitulating the Size and Cargo of Tumor Exosomes in a Tissue-Engineered Model.

Distilling complexity to advance cardiac tissue engineering.

Tissue-engineered autologous grafts for facial bone reconstruction.

Nutrient Channels Aid the Growth of Articular Surface-Sized Engineered Cartilage Constructs.

Transcriptional patterns of reverse remodeling with left ventricular assist devices: a consistent signature.

Tissue engineering of the heart: An evolving paradigm.

Erratum to: Bioengineered Models of Solid Human Tumors for Cancer Research.

Biomimetic Approaches for Bone Tissue Engineering.

Extracellular matrix components and culture regimen selectively regulate cartilage formation by self-assembling human mesenchymal stem cells in vitro and in vivo.

Tissue-Engineered Model of Human Osteolytic Bone Tumor.

Constrained Cage Culture Improves Engineered Cartilage Functional Properties by Enhancing Collagen Network Stability.

Recapitulation of physiological spatiotemporal signals promotes in vitro formation of phenotypically stable human articular cartilage.

Electromechanical Conditioning of Adult Progenitor Cells Improves Recovery of Cardiac Function After Myocardial Infarction.

Stem cell delivery in tissue-specific hydrogel enabled meniscal repair in an orthotopic rat model.

Alternative direct stem cell derivatives defined by stem cell location and graded Wnt signalling.

Ectopic implantation of juvenile osteochondral tissues recapitulates endochondral ossification.

Tissue-engineered hypertrophic chondrocyte grafts enhanced long bone repair.

Extracellular Vesicles and Their Versatile Roles in Tissue Engineering.

Tissue Engineered Bone Differentiated From Human Adipose Derived Stem Cells Inhibit Posterolateral Fusion in an Athymic Rat Model.

A microfluidic platform for the high-throughput study of pathological cardiac hypertrophy.

Functional vascularized lung grafts for lung bioengineering.

Controlled delivery and minimally invasive imaging of stem cells in the lung.

Bioreactor model of neuromuscular junction with electrical stimulation for pharmacological potency testing.

Left-Ventricular Assist Device Impact on Aortic Valve Mechanics, Proteomics and Ultrastructure.

Human bone perivascular niche-on-a-chip for studying metastatic colonization.

Perfusion Enhances Hypertrophic Chondrocyte Matrix Deposition, But Not the Bone Formation.

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development.

Testing the potency of anti-TNF-α and anti-IL-1β drugs using spheroid cultures of human osteoarthritic chondrocytes and donor-matched chondrogenically differentiated mesenchymal stem cells.

The influence of hypoxia and IFN-γ on the proteome and metabolome of therapeutic mesenchymal stem cells.

Advanced maturation of human cardiac tissue grown from pluripotent stem cells.

Chondrogenic properties of collagen type XI, a component of cartilage extracellular matrix.

Can We Engineer a Human Cardiac Patch for Therapy?

Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells.

Human Tissue-Engineered Model of Myocardial Ischemia-Reperfusion Injury.

Live imaging of stem cells in the germarium of the Drosophila ovary using a reusable gas-permeable imaging chamber.

Dual IFN-γ/hypoxia priming enhances immunosuppression of mesenchymal stromal cells through regulatory proteins and metabolic mechanisms.

Models of Ischemia-Reperfusion Injury.

Cell replacement in human lung bioengineering.

Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.

A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling.

A Multimaterial Microphysiological Platform Enabled by Rapid Casting of Elastic Microwires.

Publisher Correction: Live imaging of stem cells in the germarium of the Drosophila ovary using a reusable gas-permeable imaging chamber.

Quantification of human neuromuscular function through optogenetics.

Bioengineering approaches to organ preservation ex vivo.

Tissue engineered models of healthy and malignant human bone marrow.

Regeneration of severely damaged lungs using an interventional cross-circulation platform.

Author Correction: Advanced maturation of human cardiac tissue grown from pluripotent stem cells.

Engineering of human cardiac muscle electromechanically matured to an adult-like phenotype.

Tissue-Engineered Bone Tumor as a Reproducible Human in Vitro Model for Studies of Anticancer Drugs.

Multiday maintenance of extracorporeal lungs using cross-circulation with conscious swine.

In vitro models of neuromuscular junctions and their potential for novel drug discovery and development.

Pulsed electromagnetic fields promote repair of focal articular cartilage defects with engineered osteochondral constructs.

Heart regeneration in mouse and human: A bioengineering perspective.

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future.

Bioengineering of Pulmonary Epithelium With Preservation of the Vascular Niche.

Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs.

Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety.

Extracellular Vesicles in Cardiac Regeneration: Potential Applications for Tissues-on-a-Chip.

Tissue engineered autologous cartilage-bone grafts for temporomandibular joint regeneration.

Dynamic Hydrogels for Investigating Vascularization.

Gut bioengineering strategies for regenerative medicine.

Shortcomings of Animal Models and the Rise of Engineered Human Cardiac Tissue.

Cell type-specific microRNA therapies for myocardial infarction.

From arteries to capillaries: approaches to engineering human vasculature.

Engineered models of tumor metastasis with immune cell contributions.

Sustained Delivery of SB-431542, a Type I Transforming Growth Factor Beta-1 Receptor Inhibitor, to Prevent Arthrofibrosis.

Emerging technologies provide insights on cancer extracellular matrix biology and therapeutics.

Harnessing organs-on-a-chip to model tissue regeneration.

Machine Learning Techniques to Classify Healthy and Diseased Cardiomyocytes by Contractility Profile.

Non-destructive vacuum-assisted measurement of lung elastic modulus.

Horizontal transfer of the stemness-related markers EZH2 and GLI1 by neuroblastoma-derived extracellular vesicles in stromal cells.

Human Serum Enhances Biomimicry of Engineered Tissue Models of Bone and Cancer.

Cross-Circulation for Extracorporeal Liver Support in a Swine Model.

Bioengineered optogenetic model of human neuromuscular junction.

Organs-on-a-chip models for biological research.

milliPillar: A Platform for the Generation and Real-Time Assessment of Human Engineered Cardiac Tissues.

A framework for developing sex-specific engineered heart models.

RNA and Protein Delivery by Cell-Secreted and Bioengineered Extracellular Vesicles.

Homogeneous Distribution of Exogenous Cells onto De-epithelialized Rat Trachea via Instillation of Cell-Loaded Hydrogel.

Emerging Trajectories for Next Generation Tissue Engineers.

Bioengineering human cartilage-bone tissues for modeling of osteoarthritis.

Imaging-guided bioreactor for de-epithelialization and long-term cultivation of rat trachea.

Changes in extracellular matrix in failing human non-ischemic and ischemic hearts with mechanical unloading.

Pumping the Periosteum: A Feasibility Study: Periosteal Distraction Osteogenesis in a Rat Model.

Engineering complexity in human tissue models of cancer.

Progress in multicellular human cardiac organoids for clinical applications.