Department of Biomedical Engineering,
Department of Medicine,
College of Dental Medicine
Gordana Vunjak-Novakovic is a bioengineer appointed University Professor, the highest academic rank at Columbia University, as the first engineer in the history of Columbia to receive this highest distinction. She is also the Mikati Foundation Professor of Biomedical Engineering and Medical Sciences, Professor of Dental Medicine and a faculty in the Irving Comprehensive Cancer Center and the Center for Human Development. She directs the Laboratory for Stem Cells and Tissue Engineering, the NIH-funded Tissue Engineering Resource Center, and Columbia’s Center for Dental and Craniofacial Research. The focus of her lab is on engineering functional human tissues for use in regenerative medicine and patient-specific “organs-on-a-chip” for studies of human pathophysiology. From these studies, she published 3 books and over 450 journal articles, including those in Nature, Cell, Nature Biotechnology, Nature Medicine, Nature Biomedical Engineering, Nature Communications, Nature Protocols, Science Advances, PNAS, Cell Stem Cell, Science Translational Medicine. She has mentored over 150 trainees. With her students, she founded four biotech companies: epiBone (epibone.com), Tara (tarabiosystems.com), Xylyx (xylyxbio.com), and Immplacate (immplacatehealth.com).
Among her many recognitions, she was elected to the New York Academy of Sciences, Academia Europaea, the Serbian Academy of Sciences and Arts, the National Academy of Engineering (the first women faculty at Columbia University), the National Academy of Medicine (the first engineer at Columbia University), the National Academy of Inventors, the International Academy of Medical and Biological Engineering and the American Academy of Arts and Sciences.
Tissue engineering: the next generation.
Tissue engineering Dec, 2006 | Pubmed ID: 17518668
Engineering cartilage and bone using human mesenchymal stem cells.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association Jul, 2007 | Pubmed ID: 17657563
Silk fibroin microtubes for blood vessel engineering.
Biomaterials Dec, 2007 | Pubmed ID: 17727944
Characterization of electrical stimulation electrodes for cardiac tissue engineering.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference , 2006 | Pubmed ID: 17946862
Pre-treatment of synthetic elastomeric scaffolds by cardiac fibroblasts improves engineered heart tissue.
Journal of biomedical materials research. Part A Sep, 2008 | Pubmed ID: 18041719
Effects of chondrogenic and osteogenic regulatory factors on composite constructs grown using human mesenchymal stem cells, silk scaffolds and bioreactors.
Journal of the Royal Society, Interface Aug, 2008 | Pubmed ID: 18230586
Engineering custom-designed osteochondral tissue grafts.
Trends in biotechnology Apr, 2008 | Pubmed ID: 18299159
Cardiac tissue engineering using perfusion bioreactor systems.
Nature protocols , 2008 | Pubmed ID: 18388955
Engineering of functional cartilage tissue using stem cells from synovial lining: a preliminary study.
Clinical orthopaedics and related research Aug, 2008 | Pubmed ID: 18512111
Effects of electrical stimulation in C2C12 muscle constructs.
Journal of tissue engineering and regenerative medicine Jul, 2008 | Pubmed ID: 18512267
Effects of initial seeding density and fluid perfusion rate on formation of tissue-engineered bone.
Tissue engineering. Part A Nov, 2008 | Pubmed ID: 18620487
Synovium-derived stem cell-based chondrogenesis.
Differentiation; research in biological diversity Dec, 2008 | Pubmed ID: 18637024
Engineered microenvironments for controlled stem cell differentiation.
Tissue engineering. Part A Feb, 2009 | Pubmed ID: 18694293
The effect of devitalized trabecular bone on the formation of osteochondral tissue-engineered constructs.
Biomaterials Nov, 2008 | Pubmed ID: 18718655
Gel spinning of silk tubes for tissue engineering.
Biomaterials Dec, 2008 | Pubmed ID: 18801570
Optical mapping of impulse propagation in engineered cardiac tissue.
Tissue engineering. Part A Apr, 2009 | Pubmed ID: 18847360
Patterning stem cell differentiation.
Cell stem cell Oct, 2008 | Pubmed ID: 18940727
Micro-bioreactor arrays for controlling cellular environments: design principles for human embryonic stem cell applications.
Methods (San Diego, Calif.) Feb, 2009 | Pubmed ID: 18952171
Engineered microenvironments for human stem cells.
Birth defects research. Part C, Embryo today : reviews Dec, 2008 | Pubmed ID: 19067427
Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering.
Journal of controlled release : official journal of the Controlled Release Society Mar, 2009 | Pubmed ID: 19071168
Tissue engineered bone grafts: biological requirements, tissue culture and clinical relevance.
Current stem cell research & therapy Dec, 2008 | Pubmed ID: 19075755
Biomimetic approach to tissue engineering.
Seminars in cell & developmental biology Aug, 2009 | Pubmed ID: 19146967
Electrical stimulation systems for cardiac tissue engineering.
Nature protocols , 2009 | Pubmed ID: 19180087
Hypoxia and stem cell-based engineering of mesenchymal tissues.
Biotechnology progress Jan-Feb, 2009 | Pubmed ID: 19198002
A biocompatible endothelial cell delivery system for in vitro tissue engineering.
Cell transplantation , 2009 | Pubmed ID: 19500475
Percutaneous cell delivery into the heart using hydrogels polymerizing in situ.
Cell transplantation , 2009 | Pubmed ID: 19558778
Bone grafts engineered from human adipose-derived stem cells in perfusion bioreactor culture.
Tissue engineering. Part A Jan, 2010 | Pubmed ID: 19678762
Challenges in cardiac tissue engineering.
Tissue engineering. Part B, Reviews Apr, 2010 | Pubmed ID: 19698068
Controllable expansion of primary cardiomyocytes by reversible immortalization.
Human gene therapy Dec, 2009 | Pubmed ID: 19708763
Electrical stimulation of human embryonic stem cells: cardiac differentiation and the generation of reactive oxygen species.
Experimental cell research Dec, 2009 | Pubmed ID: 19720058
Geometry and force control of cell function.
Journal of cellular biochemistry Dec, 2009 | Pubmed ID: 19795385
Engineering anatomically shaped human bone grafts.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2010 | Pubmed ID: 19820164
Alignment and elongation of human adipose-derived stem cells in response to direct-current electrical stimulation.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference , 2009 | Pubmed ID: 19964171
Micropatterned three-dimensional hydrogel system to study human endothelial-mesenchymal stem cell interactions.
Journal of tissue engineering and regenerative medicine Mar, 2010 | Pubmed ID: 19998330
Perfusion seeding of channeled elastomeric scaffolds with myocytes and endothelial cells for cardiac tissue engineering.
Biotechnology progress Mar-Apr, 2010 | Pubmed ID: 20052737
Effects of hyperinsulinemia on lipolytic function of three-dimensional adipocyte/endothelial co-cultures.
Tissue engineering. Part C, Methods Oct, 2010 | Pubmed ID: 20144013
Biodegradable fibrous scaffolds with tunable properties formed from photo-cross-linkable poly(glycerol sebacate).
ACS applied materials & interfaces Sep, 2009 | Pubmed ID: 20160937
Adipose tissue engineering for soft tissue regeneration.
Tissue engineering. Part B, Reviews Aug, 2010 | Pubmed ID: 20166810
Spatial regulation of human mesenchymal stem cell differentiation in engineered osteochondral constructs: effects of pre-differentiation, soluble factors and medium perfusion.
Osteoarthritis and cartilage May, 2010 | Pubmed ID: 20175974
Surface-patterned electrode bioreactor for electrical stimulation.
Lab on a chip Mar, 2010 | Pubmed ID: 20221556
Bone tissue engineering with human stem cells.
Stem cell research & therapy May, 2010 | Pubmed ID: 20637059
Geometric control of human stem cell morphology and differentiation.
Integrative biology : quantitative biosciences from nano to macro Aug, 2010 | Pubmed ID: 20652175
Ingrowth of human mesenchymal stem cells into porous silk particle reinforced silk composite scaffolds: An in vitro study.
Acta biomaterialia Jan, 2011 | Pubmed ID: 20656075
Silk hydrogel for cartilage tissue engineering.
Journal of biomedical materials research. Part B, Applied biomaterials Oct, 2010 | Pubmed ID: 20725950
Tissue engineering by self-assembly and bio-printing of living cells.
Biofabrication Jun, 2010 | Pubmed ID: 20811127
Bioactive scaffolds for engineering vascularized cardiac tissues.
Macromolecular bioscience Nov, 2010 | Pubmed ID: 20857391
Patterning osteogenesis by inducible gene expression in microfluidic culture systems.
Integrative biology : quantitative biosciences from nano to macro Jan, 2011 | Pubmed ID: 20924519
Microfluidic device generating stable concentration gradients for long term cell culture: application to Wnt3a regulation of β-catenin signaling.
Lab on a chip Dec, 2010 | Pubmed ID: 20936235
Scaffold stiffness affects the contractile function of three-dimensional engineered cardiac constructs.
Biotechnology progress Sep-Oct, 2010 | Pubmed ID: 20945492
Adipogenic differentiation of human adipose-derived stem cells on 3D silk scaffolds.
Methods in molecular biology (Clifton, N.J.) , 2011 | Pubmed ID: 21082412
Adipose tissue as a stem cell source for musculoskeletal regeneration.
Frontiers in bioscience (Scholar edition) 01, 2011 | Pubmed ID: 21196358
Tubular silk scaffolds for small diameter vascular grafts.
Organogenesis Oct-Dec, 2010 | Pubmed ID: 21220960
Lipolytic function of adipocyte/endothelial cocultures.
Tissue engineering. Part A May, 2011 | Pubmed ID: 21247356
Nucleation and growth of mineralized bone matrix on silk-hydroxyapatite composite scaffolds.
Biomaterials Apr, 2011 | Pubmed ID: 21262535
Potential pathophysiological mechanisms in osteonecrosis of the jaw.
Annals of the New York Academy of Sciences Feb, 2011 | Pubmed ID: 21291478
Biomimetic platforms for human stem cell research.
Cell stem cell Mar, 2011 | Pubmed ID: 21362565
Bioreactor cultivation of functional bone grafts.
Methods in molecular biology (Clifton, N.J.) , 2011 | Pubmed ID: 21431523
Optimizing the medium perfusion rate in bone tissue engineering bioreactors.
Biotechnology and bioengineering May, 2011 | Pubmed ID: 21449028
Composite scaffold provides a cell delivery platform for cardiovascular repair.
Proceedings of the National Academy of Sciences of the United States of America May, 2011 | Pubmed ID: 21508321
Bioengineering heart muscle: a paradigm for regenerative medicine.
Annual review of biomedical engineering Aug, 2011 | Pubmed ID: 21568715
Optimization of electrical stimulation parameters for cardiac tissue engineering.
Journal of tissue engineering and regenerative medicine Jun, 2011 | Pubmed ID: 21604379
Micropatterned mammalian cells exhibit phenotype-specific left-right asymmetry.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2011 | Pubmed ID: 21709270
Derivation of two new human embryonic stem cell lines from nonviable human embryos.
Stem cells international , 2011 | Pubmed ID: 21716665
Hybrid gel composed of native heart matrix and collagen induces cardiac differentiation of human embryonic stem cells without supplemental growth factors.
Journal of cardiovascular translational research Oct, 2011 | Pubmed ID: 21744185
In vitro platforms for tissue engineering: implications for basic research and clinical translation.
Journal of tissue engineering and regenerative medicine Aug, 2011 | Pubmed ID: 21774080
Effects of pamidronate on human alveolar osteoblasts in vitro.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons May, 2012 | Pubmed ID: 21856057
Optimizing dynamic interactions between a cardiac patch and inflammatory host cells.
Cells, tissues, organs , 2012 | Pubmed ID: 21996612
Time-dependent processes in stem cell-based tissue engineering of articular cartilage.
Stem cell reviews and reports Sep, 2012 | Pubmed ID: 22016073
Channelled scaffolds for engineering myocardium with mechanical stimulation.
Journal of tissue engineering and regenerative medicine Oct, 2012 | Pubmed ID: 22081518
Engineering tissue with BioMEMS.
IEEE pulse Nov, 2011 | Pubmed ID: 22147066
In vitro model of vascularized bone: synergizing vascular development and osteogenesis.
PloS one , 2011 | Pubmed ID: 22164277
Biomimetic perfusion and electrical stimulation applied in concert improved the assembly of engineered cardiac tissue.
Journal of tissue engineering and regenerative medicine Nov, 2012 | Pubmed ID: 22170772
Development of silk-based scaffolds for tissue engineering of bone from human adipose-derived stem cells.
Acta biomaterialia Jul, 2012 | Pubmed ID: 22421311
Micropatterning chiral morphogenesis.
Communicative & integrative biology Nov, 2011 | Pubmed ID: 22446544
Vascular endothelial growth factor secretion by nonmyocytes modulates Connexin-43 levels in cardiac organoids.
Tissue engineering. Part A Sep, 2012 | Pubmed ID: 22519405
Engineering bone tissue from human embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America May, 2012 | Pubmed ID: 22586099
Biofabrication enables efficient interrogation and optimization of sequential culture of endothelial cells, fibroblasts and cardiomyocytes for formation of vascular cords in cardiac tissue engineering.
Biofabrication Sep, 2012 | Pubmed ID: 22846187
Bone scaffold architecture modulates the development of mineralized bone matrix by human embryonic stem cells.
Biomaterials Nov, 2012 | Pubmed ID: 22901965
Macrophages modulate the viability and growth of human mesenchymal stem cells.
Journal of cellular biochemistry Jan, 2013 | Pubmed ID: 22903635
Human adipose-derived cells can serve as a single-cell source for the in vitro cultivation of vascularized bone grafts.
Journal of tissue engineering and regenerative medicine Aug, 2014 | Pubmed ID: 22903929
The effect of controlled expression of VEGF by transduced myoblasts in a cardiac patch on vascularization in a mouse model of myocardial infarction.
Biomaterials Jan, 2013 | Pubmed ID: 23083931
Concise review: personalized human bone grafts for reconstructing head and face.
Stem cells translational medicine Jan, 2012 | Pubmed ID: 23197642
Transient hypoxia improves matrix properties in tissue engineered cartilage.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Apr, 2013 | Pubmed ID: 23203946
Microfluidic bioreactor for dynamic regulation of early mesodermal commitment in human pluripotent stem cells.
Lab on a chip Feb, 2013 | Pubmed ID: 23232509
Sequential application of steady and pulsatile medium perfusion enhanced the formation of engineered bone.
Tissue engineering. Part A May, 2013 | Pubmed ID: 23259605
Tissue engineering strategies for skeletal repair.
HSS journal : the musculoskeletal journal of Hospital for Special Surgery Feb, 2012 | Pubmed ID: 23372533
Assembly of complex cell microenvironments using geometrically docked hydrogel shapes.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2013 | Pubmed ID: 23487790
Bioreactor engineering of stem cell environments.
Biotechnology advances Nov, 2013 | Pubmed ID: 23531529
Insulin, ascorbate, and glucose have a much greater influence than transferrin and selenous acid on the in vitro growth of engineered cartilage in chondrogenic media.
Tissue engineering. Part A Sep, 2013 | Pubmed ID: 23544890
Cartilage constructs engineered from chondrocytes overexpressing IGF-I improve the repair of osteochondral defects in a rabbit model.
European cells & materials Apr, 2013 | Pubmed ID: 23588785
Noninvasive imaging of myocyte apoptosis following application of a stem cell-engineered delivery platform to acutely infarcted myocardium.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Jun, 2013 | Pubmed ID: 23616583
Supplementation of exogenous adenosine 5'-triphosphate enhances mechanical properties of 3D cell-agarose constructs for cartilage tissue engineering.
Tissue engineering. Part A Oct, 2013 | Pubmed ID: 23651296
Engineering bone tissue substitutes from human induced pluripotent stem cells.
Proceedings of the National Academy of Sciences of the United States of America May, 2013 | Pubmed ID: 23653480
Micropatterning of cells reveals chiral morphogenesis.
Stem cell research & therapy Apr, 2013 | Pubmed ID: 23672821
Patterning pluripotency in embryonic stem cells.
Stem cells (Dayton, Ohio) Sep, 2013 | Pubmed ID: 23843329
Decellularization of human and porcine lung tissues for pulmonary tissue engineering.
The Annals of thoracic surgery Sep, 2013 | Pubmed ID: 23870827
Age-related carbonylation of fibrocartilage structural proteins drives tissue degenerative modification.
Chemistry & biology Jul, 2013 | Pubmed ID: 23890010
In vitro mesenchymal trilineage differentiation and extracellular matrix production by adipose and bone marrow derived adult equine multipotent stromal cells on a collagen scaffold.
Stem cell reviews and reports Dec, 2013 | Pubmed ID: 23892935
Bioengineering heart tissue for in vitro testing.
Current opinion in biotechnology Oct, 2013 | Pubmed ID: 23932513
The regulation of growth and metabolism of kidney stem cells with regional specificity using extracellular matrix derived from kidney.
Biomaterials Dec, 2013 | Pubmed ID: 24074840
Electrical stimulation via a biocompatible conductive polymer directs retinal progenitor cell differentiation.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference Jul, 2013 | Pubmed ID: 24110015
Biomimetic electrical stimulation platform for neural differentiation of retinal progenitor cells.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference , 2013 | Pubmed ID: 24111023
Portable bioreactor for perfusion and electrical stimulation of engineered cardiac tissue.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference , 2013 | Pubmed ID: 24111161
Galvanic microparticles increase migration of human dermal fibroblasts in a wound-healing model via reactive oxygen species pathway.
Experimental cell research Jan, 2014 | Pubmed ID: 24113575
Biomimetic scaffold combined with electrical stimulation and growth factor promotes tissue engineered cardiac development.
Experimental cell research Feb, 2014 | Pubmed ID: 24240126
Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
Nature biotechnology Jan, 2014 | Pubmed ID: 24291815
Electrically conductive chitosan/carbon scaffolds for cardiac tissue engineering.
Biomacromolecules Feb, 2014 | Pubmed ID: 24417502
Electrical stimulation enhances cell migration and integrative repair in the meniscus.
Scientific reports Jan, 2014 | Pubmed ID: 24419206
The current status of iPS cells in cardiac research and their potential for tissue engineering and regenerative medicine.
Stem cell reviews and reports Apr, 2014 | Pubmed ID: 24425421
Physical influences on stem cells.
Stem cell research & therapy Dec, 2013 | Pubmed ID: 24476419
HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease.
Stem cell research & therapy , 2013 | Pubmed ID: 24565063
The role of macrophage phenotype in vascularization of tissue engineering scaffolds.
Biomaterials May, 2014 | Pubmed ID: 24589361
Myocardial tissue engineering: in vitro models.
Cold Spring Harbor perspectives in medicine Mar, 2014 | Pubmed ID: 24591534
Microscale technologies for regulating human stem cell differentiation.
Experimental biology and medicine (Maywood, N.J.) Sep, 2014 | Pubmed ID: 24737735
Bioengineered human tumor within a bone niche.
Biomaterials Jul, 2014 | Pubmed ID: 24746967
Large, stratified, and mechanically functional human cartilage grown in vitro by mesenchymal condensation.
Proceedings of the National Academy of Sciences of the United States of America May, 2014 | Pubmed ID: 24778247
Natural cardiac extracellular matrix hydrogels for cultivation of human stem cell-derived cardiomyocytes.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 25070328
Silk microfiber-reinforced silk hydrogel composites for functional cartilage tissue repair.
Acta biomaterialia Jan, 2015 | Pubmed ID: 25281788
Endothelial cells enhance the migration of bovine meniscus cells.
Arthritis & rheumatology (Hoboken, N.J.) Jan, 2015 | Pubmed ID: 25307081
Macrophages modulate engineered human tissues for enhanced vascularization and healing.
Annals of biomedical engineering Mar, 2015 | Pubmed ID: 25331098
Hierarchically ordered nanopatterns for spatial control of biomolecules.
ACS nano Nov, 2014 | Pubmed ID: 25363506
Bupivacaine mandibular nerve block affects intraoperative blood pressure and heart rate in a Yucatan miniature swine mandibular condylectomy model: a pilot study.
Journal of investigative surgery : the official journal of the Academy of Surgical Research Feb, 2015 | Pubmed ID: 25394295
Passage-dependent relationship between mesenchymal stem cell mobilization and chondrogenic potential.
Osteoarthritis and cartilage Feb, 2015 | Pubmed ID: 25452155
Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds.
Biomaterials Jan, 2015 | Pubmed ID: 25453950
Nutrient channels and stirring enhanced the composition and stiffness of large cartilage constructs.
Journal of biomechanics Dec, 2014 | Pubmed ID: 25458579
Matrix Production in Large Engineered Cartilage Constructs Is Enhanced by Nutrient Channels and Excess Media Supply.
Tissue engineering. Part C, Methods Jul, 2015 | Pubmed ID: 25526931
Bioengineered tumors.
Bioengineered , 2015 | Pubmed ID: 25616977
Synergistic effects of hypoxia and morphogenetic factors on early chondrogenic commitment of human embryonic stem cells in embryoid body culture.
Stem cell reviews and reports Apr, 2015 | Pubmed ID: 25618295
Tissue-engineered models of human tumors for cancer research.
Expert opinion on drug discovery Mar, 2015 | Pubmed ID: 25662589
Clinical translation of controlled protein delivery systems for tissue engineering.
Drug delivery and translational research Apr, 2015 | Pubmed ID: 25787736
Engineering physiologically stiff and stratified human cartilage by fusing condensed mesenchymal stem cells.
Methods (San Diego, Calif.) Aug, 2015 | Pubmed ID: 25828645
Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation.
Biomaterials Aug, 2015 | Pubmed ID: 25985155
"The state of the heart": Recent advances in engineering human cardiac tissue from pluripotent stem cells.
Experimental biology and medicine (Maywood, N.J.) Aug, 2015 | Pubmed ID: 26069271
Advanced methods for tissue engineering and regenerative medicine.
Methods (San Diego, Calif.) Aug, 2015 | Pubmed ID: 26117581
Bioengineering methods for myocardial regeneration.
Advanced drug delivery reviews Jan, 2016 | Pubmed ID: 26150344
Introducer Development for Coronary Sinus Access From Parasternal Mediastinotomy.
Innovations (Philadelphia, Pa.) May-Jun, 2015 | Pubmed ID: 26181586
Challenges in engineering osteochondral tissue grafts with hierarchical structures.
Expert opinion on biological therapy , 2015 | Pubmed ID: 26195329
Targeted delivery of liquid microvolumes into the lung.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2015 | Pubmed ID: 26324893
Cardiac biology: A protein for healing infarcted hearts.
Nature Sep, 2015 | Pubmed ID: 26375007
Controlled release of cytokines using silk-biomaterials for macrophage polarization.
Biomaterials Dec, 2015 | Pubmed ID: 26421484
Rapid retraction of microvolume aqueous plugs traveling in a wettable capillary.
Applied physics letters Oct, 2015 | Pubmed ID: 26487787
Differential gene expression in human, murine, and cell line-derived macrophages upon polarization.
Experimental cell research Sep, 2016 | Pubmed ID: 26500109
Heterogeneous engineered cartilage growth results from gradients of media-supplemented active TGF-β and is ameliorated by the alternative supplementation of latent TGF-β.
Biomaterials Jan, 2016 | Pubmed ID: 26599624
Tissue Engineering and Regenerative Medicine 2015: A Year in Review.
Tissue engineering. Part B, Reviews Apr, 2016 | Pubmed ID: 26714410
Tissue-Engineering for the Study of Cardiac Biomechanics.
Journal of biomechanical engineering Feb, 2016 | Pubmed ID: 26720588
Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes.
Nature communications Jan, 2016 | Pubmed ID: 26785135
Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue.
Advanced healthcare materials Apr, 2016 | Pubmed ID: 26865105
Immune modulation as a therapeutic strategy in bone regeneration.
Journal of experimental orthopaedics Dec, 2015 | Pubmed ID: 26914869
Should we use cells, biomaterials, or tissue engineering for cartilage regeneration?
Stem cell research & therapy Apr, 2016 | Pubmed ID: 27089917
Bioengineered Models of Solid Human Tumors for Cancer Research.
Methods in molecular biology (Clifton, N.J.) , 2016 | Pubmed ID: 27115504
Modeling tumor microenvironments using custom-designed biomaterial scaffolds.
Current opinion in chemical engineering Feb, 2016 | Pubmed ID: 27152253
High seeding density of human chondrocytes in agarose produces tissue-engineered cartilage approaching native mechanical and biochemical properties.
Journal of biomechanics 06, 2016 | Pubmed ID: 27198889
Mesenchymal Stem Cells for Osteochondral Tissue Engineering.
Methods in molecular biology (Clifton, N.J.) , 2016 | Pubmed ID: 27236665
Optimizing nutrient channel spacing and revisiting TGF-beta in large engineered cartilage constructs.
Journal of biomechanics 07, 2016 | Pubmed ID: 27255605
Recapitulating the Size and Cargo of Tumor Exosomes in a Tissue-Engineered Model.
Theranostics , 2016 | Pubmed ID: 27279906
Distilling complexity to advance cardiac tissue engineering.
Science translational medicine Jun, 2016 | Pubmed ID: 27280684
Tissue-engineered autologous grafts for facial bone reconstruction.
Science translational medicine 06, 2016 | Pubmed ID: 27306665
Nutrient Channels Aid the Growth of Articular Surface-Sized Engineered Cartilage Constructs.
Tissue engineering. Part A 09, 2016 | Pubmed ID: 27481330
Transcriptional patterns of reverse remodeling with left ventricular assist devices: a consistent signature.
Expert review of medical devices Nov, 2016 | Pubmed ID: 27685648
Tissue engineering of the heart: An evolving paradigm.
The Journal of thoracic and cardiovascular surgery 03, 2017 | Pubmed ID: 27692954
Erratum to: Bioengineered Models of Solid Human Tumors for Cancer Research.
Methods in molecular biology (Clifton, N.J.) , 2016 | Pubmed ID: 27900738
Biomimetic Approaches for Bone Tissue Engineering.
Tissue engineering. Part B, Reviews 10, 2017 | Pubmed ID: 27912680
Extracellular matrix components and culture regimen selectively regulate cartilage formation by self-assembling human mesenchymal stem cells in vitro and in vivo.
Stem cell research & therapy 12, 2016 | Pubmed ID: 27931263
Tissue-Engineered Model of Human Osteolytic Bone Tumor.
Tissue engineering. Part C, Methods 02, 2017 | Pubmed ID: 28068876
Constrained Cage Culture Improves Engineered Cartilage Functional Properties by Enhancing Collagen Network Stability.
Tissue engineering. Part A 08, 2017 | Pubmed ID: 28193145
Recapitulation of physiological spatiotemporal signals promotes in vitro formation of phenotypically stable human articular cartilage.
Proceedings of the National Academy of Sciences of the United States of America 03, 2017 | Pubmed ID: 28228529
Electromechanical Conditioning of Adult Progenitor Cells Improves Recovery of Cardiac Function After Myocardial Infarction.
Stem cells translational medicine 03, 2017 | Pubmed ID: 28297585
Stem cell delivery in tissue-specific hydrogel enabled meniscal repair in an orthotopic rat model.
Biomaterials 07, 2017 | Pubmed ID: 28407495
Alternative direct stem cell derivatives defined by stem cell location and graded Wnt signalling.
Nature cell biology May, 2017 | Pubmed ID: 28414313
Ectopic implantation of juvenile osteochondral tissues recapitulates endochondral ossification.
Journal of tissue engineering and regenerative medicine 02, 2018 | Pubmed ID: 28600846
Tissue-engineered hypertrophic chondrocyte grafts enhanced long bone repair.
Biomaterials Sep, 2017 | Pubmed ID: 28622604
Extracellular Vesicles and Their Versatile Roles in Tissue Engineering.
Tissue engineering. Part A 11, 2017 | Pubmed ID: 28649910
Tissue Engineered Bone Differentiated From Human Adipose Derived Stem Cells Inhibit Posterolateral Fusion in an Athymic Rat Model.
Spine 04, 2018 | Pubmed ID: 28816826
A microfluidic platform for the high-throughput study of pathological cardiac hypertrophy.
Lab on a chip 09, 2017 | Pubmed ID: 28832065
Functional vascularized lung grafts for lung bioengineering.
Science advances 08, 2017 | Pubmed ID: 28875163
Controlled delivery and minimally invasive imaging of stem cells in the lung.
Scientific reports 10, 2017 | Pubmed ID: 29026127
Bioreactor model of neuromuscular junction with electrical stimulation for pharmacological potency testing.
Integrative biology : quantitative biosciences from nano to macro Dec, 2017 | Pubmed ID: 29168874
Left-Ventricular Assist Device Impact on Aortic Valve Mechanics, Proteomics and Ultrastructure.
The Annals of thoracic surgery Feb, 2018 | Pubmed ID: 29223417
Human bone perivascular niche-on-a-chip for studying metastatic colonization.
Proceedings of the National Academy of Sciences of the United States of America 02, 2018 | Pubmed ID: 29363599
Perfusion Enhances Hypertrophic Chondrocyte Matrix Deposition, But Not the Bone Formation.
Tissue engineering. Part A 06, 2018 | Pubmed ID: 29373945
Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development.
Cell stem cell 03, 2018 | Pubmed ID: 29499151
Testing the potency of anti-TNF-α and anti-IL-1β drugs using spheroid cultures of human osteoarthritic chondrocytes and donor-matched chondrogenically differentiated mesenchymal stem cells.
Biotechnology progress 07, 2018 | Pubmed ID: 29536646
The influence of hypoxia and IFN-γ on the proteome and metabolome of therapeutic mesenchymal stem cells.
Biomaterials 06, 2018 | Pubmed ID: 29574308
Advanced maturation of human cardiac tissue grown from pluripotent stem cells.
Nature 04, 2018 | Pubmed ID: 29618819
Chondrogenic properties of collagen type XI, a component of cartilage extracellular matrix.
Biomaterials 08, 2018 | Pubmed ID: 29758546
Can We Engineer a Human Cardiac Patch for Therapy?
Circulation research Jul, 2018 | Pubmed ID: 29976691
Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells.
Nature biomedical engineering May, 2018 | Pubmed ID: 30271672
Human Tissue-Engineered Model of Myocardial Ischemia-Reperfusion Injury.
Tissue engineering. Part A 05, 2019 | Pubmed ID: 30311860
Live imaging of stem cells in the germarium of the Drosophila ovary using a reusable gas-permeable imaging chamber.
Nature protocols 11, 2018 | Pubmed ID: 30349048
Dual IFN-γ/hypoxia priming enhances immunosuppression of mesenchymal stromal cells through regulatory proteins and metabolic mechanisms.
Journal of immunology and regenerative medicine Mar, 2018 | Pubmed ID: 30364570
Models of Ischemia-Reperfusion Injury.
Regenerative engineering and translational medicine Sep, 2018 | Pubmed ID: 30393757
Cell replacement in human lung bioengineering.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 02, 2019 | Pubmed ID: 30529200
Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.
Circulation research Jan, 2019 | Pubmed ID: 30605412
A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling.
Cell 02, 2019 | Pubmed ID: 30686581
A Multimaterial Microphysiological Platform Enabled by Rapid Casting of Elastic Microwires.
Advanced healthcare materials 03, 2019 | Pubmed ID: 30737909
Publisher Correction: Live imaging of stem cells in the germarium of the Drosophila ovary using a reusable gas-permeable imaging chamber.
Nature protocols Aug, 2019 | Pubmed ID: 30770888
Quantification of human neuromuscular function through optogenetics.
Theranostics , 2019 | Pubmed ID: 30867827
Bioengineering approaches to organ preservation ex vivo.
Experimental biology and medicine (Maywood, N.J.) 05, 2019 | Pubmed ID: 30889963
Tissue engineered models of healthy and malignant human bone marrow.
Advanced drug delivery reviews 02, 2019 | Pubmed ID: 31002835
Regeneration of severely damaged lungs using an interventional cross-circulation platform.
Nature communications 05, 2019 | Pubmed ID: 31064987
Author Correction: Advanced maturation of human cardiac tissue grown from pluripotent stem cells.
Nature Aug, 2019 | Pubmed ID: 31363231
Engineering of human cardiac muscle electromechanically matured to an adult-like phenotype.
Nature protocols 10, 2019 | Pubmed ID: 31492957
Tissue-Engineered Bone Tumor as a Reproducible Human in Vitro Model for Studies of Anticancer Drugs.
Toxicological sciences : an official journal of the Society of Toxicology 01, 2020 | Pubmed ID: 31626302
Multiday maintenance of extracorporeal lungs using cross-circulation with conscious swine.
The Journal of thoracic and cardiovascular surgery 04, 2020 | Pubmed ID: 31761338
In vitro models of neuromuscular junctions and their potential for novel drug discovery and development.
Expert opinion on drug discovery 03, 2020 | Pubmed ID: 31846349
Pulsed electromagnetic fields promote repair of focal articular cartilage defects with engineered osteochondral constructs.
Biotechnology and bioengineering 05, 2020 | Pubmed ID: 31985051
Heart regeneration in mouse and human: A bioengineering perspective.
Current opinion in physiology , | Pubmed ID: 32095673
The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future.
Cell stem cell 04, 2020 | Pubmed ID: 32243808
Bioengineering of Pulmonary Epithelium With Preservation of the Vascular Niche.
Frontiers in bioengineering and biotechnology , 2020 | Pubmed ID: 32351946
Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs.
Nature medicine 07, 2020 | Pubmed ID: 32661401
Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety.
Lab on a chip 11, 2020 | Pubmed ID: 32955072
Extracellular Vesicles in Cardiac Regeneration: Potential Applications for Tissues-on-a-Chip.
Trends in biotechnology 08, 2021 | Pubmed ID: 32958383
Tissue engineered autologous cartilage-bone grafts for temporomandibular joint regeneration.
Science translational medicine 10, 2020 | Pubmed ID: 33055244
Dynamic Hydrogels for Investigating Vascularization.
Cell stem cell 11, 2020 | Pubmed ID: 33157044
Gut bioengineering strategies for regenerative medicine.
American journal of physiology. Gastrointestinal and liver physiology 01, 2021 | Pubmed ID: 33174453
Shortcomings of Animal Models and the Rise of Engineered Human Cardiac Tissue.
ACS biomaterials science & engineering , | Pubmed ID: 33440547
Cell type-specific microRNA therapies for myocardial infarction.
Science translational medicine 02, 2021 | Pubmed ID: 33568517
From arteries to capillaries: approaches to engineering human vasculature.
Advanced functional materials Sep, 2020 | Pubmed ID: 33708027
Engineered models of tumor metastasis with immune cell contributions.
iScience Mar, 2021 | Pubmed ID: 33718831
Sustained Delivery of SB-431542, a Type I Transforming Growth Factor Beta-1 Receptor Inhibitor, to Prevent Arthrofibrosis.
Tissue engineering. Part A 11, 2021 | Pubmed ID: 33752445
Emerging technologies provide insights on cancer extracellular matrix biology and therapeutics.
iScience May, 2021 | Pubmed ID: 34027324
Harnessing organs-on-a-chip to model tissue regeneration.
Cell stem cell 06, 2021 | Pubmed ID: 34087161
Machine Learning Techniques to Classify Healthy and Diseased Cardiomyocytes by Contractility Profile.
ACS biomaterials science & engineering 07, 2021 | Pubmed ID: 34152732
Non-destructive vacuum-assisted measurement of lung elastic modulus.
Acta biomaterialia 09, 2021 | Pubmed ID: 34192570
Horizontal transfer of the stemness-related markers EZH2 and GLI1 by neuroblastoma-derived extracellular vesicles in stromal cells.
Translational research : the journal of laboratory and clinical medicine 11, 2021 | Pubmed ID: 34217898
Human Serum Enhances Biomimicry of Engineered Tissue Models of Bone and Cancer.
Frontiers in bioengineering and biotechnology , 2021 | Pubmed ID: 34327193
Cross-Circulation for Extracorporeal Liver Support in a Swine Model.
ASAIO journal (American Society for Artificial Internal Organs : 1992) Aug, 2021 | Pubmed ID: 34352819
Bioengineered optogenetic model of human neuromuscular junction.
Biomaterials 09, 2021 | Pubmed ID: 34403849
Organs-on-a-chip models for biological research.
Cell 09, 2021 | Pubmed ID: 34478657
milliPillar: A Platform for the Generation and Real-Time Assessment of Human Engineered Cardiac Tissues.
ACS biomaterials science & engineering 11, 2021 | Pubmed ID: 34668692
A framework for developing sex-specific engineered heart models.
Nature reviews. Materials Oct, 2021 | Pubmed ID: 34691764
RNA and Protein Delivery by Cell-Secreted and Bioengineered Extracellular Vesicles.
Advanced healthcare materials Mar, 2022 | Pubmed ID: 34706168
Homogeneous Distribution of Exogenous Cells onto De-epithelialized Rat Trachea via Instillation of Cell-Loaded Hydrogel.
ACS biomaterials science & engineering 01, 2022 | Pubmed ID: 34874712
Emerging Trajectories for Next Generation Tissue Engineers.
ACS biomaterials science & engineering Dec, 2021 | Pubmed ID: 34878769
Bioengineering human cartilage-bone tissues for modeling of osteoarthritis.
Stem cells and development Jan, 2022 | Pubmed ID: 35088600
Imaging-guided bioreactor for de-epithelialization and long-term cultivation of rat trachea.
Lab on a chip 03, 2022 | Pubmed ID: 35166739
Changes in extracellular matrix in failing human non-ischemic and ischemic hearts with mechanical unloading.
Journal of molecular and cellular cardiology Feb, 2022 | Pubmed ID: 35219725
Pumping the Periosteum: A Feasibility Study: Periosteal Distraction Osteogenesis in a Rat Model.
Annals of plastic surgery Mar, 2022 | Pubmed ID: 35276708
Engineering complexity in human tissue models of cancer.
Advanced drug delivery reviews Mar, 2022 | Pubmed ID: 35278521
Progress in multicellular human cardiac organoids for clinical applications.
Cell stem cell Apr, 2022 | Pubmed ID: 35395186
1Department of Biomedical Engineering, Rensselaer Polytechnic Institute,
2Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute,
3Department of Biomedical Engineering, Columbia University,
4Department of Medicine, Columbia University,
5Department of Biological Sciences, Rensselaer Polytechnic Institute,
6Center for Modeling, Simulation, and Imaging in Medicine, Rensselaer Polytechnic Institute
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