Departments of Physiology and Neurobiology,
Department of Physiology
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Control of P2X(2) channel permeability by the cytosolic domain.
The Journal of general physiology Aug, 2002 | Pubmed ID: 12149275
ATP modulation of excitatory synapses onto interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience Aug, 2003 | Pubmed ID: 12917379
ATP-gated P2X channels.
Current biology : CB Jan, 2004 | Pubmed ID: 14711422
Contribution of calcium ions to P2X channel responses.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2004 | Pubmed ID: 15056721
ATP excites interneurons and astrocytes to increase synaptic inhibition in neuronal networks.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2004 | Pubmed ID: 15456834
Time-resolved measurement of state-specific P2X2 ion channel cytosolic gating motions.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2004 | Pubmed ID: 15548662
Contribution of transmembrane regions to ATP-gated P2X2 channel permeability dynamics.
The Journal of biological chemistry Feb, 2005 | Pubmed ID: 15556949
An angstrom scale interaction between plasma membrane ATP-gated P2X2 and alpha4beta2 nicotinic channels measured with fluorescence resonance energy transfer and total internal reflection fluorescence microscopy.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2005 | Pubmed ID: 16033901
P2X receptors as cell-surface ATP sensors in health and disease.
Nature Aug, 2006 | Pubmed ID: 16885977
Two forms of single-vesicle astrocyte exocytosis imaged with total internal reflection fluorescence microscopy.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2007 | Pubmed ID: 17360502
Vesicular ATP is the predominant cause of intercellular calcium waves in astrocytes.
The Journal of general physiology Jun, 2007 | Pubmed ID: 17504911
Tracking transmitter-gated P2X cation channel activation in vitro and in vivo.
Nature methods Jan, 2008 | Pubmed ID: 18084300
Two forms of astrocyte calcium excitability have distinct effects on NMDA receptor-mediated slow inward currents in pyramidal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2008 | Pubmed ID: 18579739
ATP-gated P2X receptors on excitatory nerve terminals onto interneurons initiate a form of asynchronous glutamate release.
Neuropharmacology Jan, 2009 | Pubmed ID: 18601937
Molecular shape, architecture, and size of P2X4 receptors determined using fluorescence resonance energy transfer and electron microscopy.
The Journal of biological chemistry Sep, 2008 | Pubmed ID: 18635539
ATP-gated P2X cation-channels.
Neuropharmacology Jan, 2009 | Pubmed ID: 18657557
Patch-clamp coordinated spectroscopy shows P2X2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2008 | Pubmed ID: 18689682
Tunable calcium current through TRPV1 receptor channels.
The Journal of biological chemistry Nov, 2008 | Pubmed ID: 18775990
Regulation of P2X2 receptors by the neuronal calcium sensor VILIP1.
Science signaling , 2008 | Pubmed ID: 18922787
The double life of ATP.
Scientific American Dec, 2009 | Pubmed ID: 20058644
Gated access to the pore of a P2X receptor: structural implications for closed-open transitions.
The Journal of biological chemistry Mar, 2010 | Pubmed ID: 20093367
P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin.
The Journal of general physiology Apr, 2010 | Pubmed ID: 20231374
A genetically targeted optical sensor to monitor calcium signals in astrocyte processes.
Nature neuroscience Jun, 2010 | Pubmed ID: 20495558
Monitoring astrocyte calcium microdomains with improved membrane targeted GCaMP reporters.
Neuron glia biology Dec, 2010 | Pubmed ID: 21205365
Bulk loading of calcium indicator dyes to study astrocyte physiology: key limitations and improvements using morphological maps.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2011 | Pubmed ID: 21697385
Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors).
Proceedings of the National Academy of Sciences of the United States of America Aug, 2011 | Pubmed ID: 21808018
Neuronal P2X2 receptors are mobile ATP sensors that explore the plasma membrane when activated.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2011 | Pubmed ID: 22090499
TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3.
Nature neuroscience Jan, 2012 | Pubmed ID: 22158513
Allosteric modulation of Ca2+ flux in a ligand-gated cation channel (P2X4) by actions on lateral portals.
The Journal of biological chemistry Jan, 2012 | Pubmed ID: 22219189
Imaging P2X4 receptor lateral mobility in microglia: regulation by calcium and p38 MAPK.
The Journal of biological chemistry Apr, 2012 | Pubmed ID: 22393055
Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2012 | Pubmed ID: 23035093
Neuromodulation by extracellular ATP and P2X receptors in the CNS.
Neuron Oct, 2012 | Pubmed ID: 23040806
Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2012 | Pubmed ID: 23077035
Genetically encoded calcium indicators and astrocyte calcium microdomains.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry Jun, 2013 | Pubmed ID: 23264008
Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses.
The Journal of general physiology May, 2013 | Pubmed ID: 23589582
ATP-gated ion channels mediate adaptation to elevated sound levels.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2013 | Pubmed ID: 23592720
TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2013 | Pubmed ID: 23761909
Tunable diblock copolypeptide hydrogel depots for local delivery of hydrophobic molecules in healthy and injured central nervous system.
Biomaterials Feb, 2014 | Pubmed ID: 24314556
Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice.
Nature neuroscience May, 2014 | Pubmed ID: 24686787
Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.
The Journal of biological chemistry May, 2014 | Pubmed ID: 24706758
Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway.
Neuron Apr, 2014 | Pubmed ID: 24742463
Astrocytes and Huntington's disease.
ACS chemical neuroscience Jul, 2014 | Pubmed ID: 24842291
Imaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorin.
The Journal of general physiology Jul, 2014 | Pubmed ID: 24935743
Slow neuromodulation mediated by ATP P2X receptors.
Neuron Jul, 2014 | Pubmed ID: 25033174
ATP-gated P2X receptors in health and disease.
Frontiers in cellular neuroscience , 2014 | Pubmed ID: 25104924
Ca(2+) signaling in astrocytes from Ip3r2(-/-) mice in brain slices and during startle responses in vivo.
Nature neuroscience May, 2015 | Pubmed ID: 25894291
Diversity of astrocyte functions and phenotypes in neural circuits.
Nature neuroscience Jul, 2015 | Pubmed ID: 26108722
Probing the Complexities of Astrocyte Calcium Signaling.
Trends in cell biology Apr, 2016 | Pubmed ID: 26896246
Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2016 | Pubmed ID: 27013675
Astrocyte scar formation aids central nervous system axon regeneration.
Nature Apr, 2016 | Pubmed ID: 27027288
P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 08, 2016 | Pubmed ID: 27559172
New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo.
Neuron Dec, 2016 | Pubmed ID: 27939582
Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease.
Trends in neurosciences 07, 2017 | Pubmed ID: 28578789
Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
Neuron Aug, 2017 | Pubmed ID: 28712653
An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales.
Neuron Apr, 2018 | Pubmed ID: 29621490
Active role of capillary pericytes during stimulation-induced activity and spreading depolarization.
Brain : a journal of neurology 07, 2018 | Pubmed ID: 30053174
Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior.
Neuron 09, 2018 | Pubmed ID: 30174118
A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP.
Nature communications 02, 2019 | Pubmed ID: 30755613
Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue.
Cell May, 2019 | Pubmed ID: 31031006
Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation.
Cell reports May, 2019 | Pubmed ID: 31116972
The Emerging Nature of Astrocyte Diversity.
Annual review of neuroscience Jul, 2019 | Pubmed ID: 31283899
Astrocyte-Neuron Interactions in the Striatum: Insights on Identity, Form, and Function.
Trends in neurosciences Sep, 2019 | Pubmed ID: 31351745
1Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles,
2Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles,
3Department of Anesthesiology, Medicine and Physiology, David Geffen School of Medicine, University of California, Los Angeles