Evaluating Toxicity of Chemicals using a Zebrafish Vibration Startle Response Screening System

1.3K Views

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06:25 min

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January 12th, 2024

DOI :

10.3791/66153-v

January 12th, 2024

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Gaëlle Hayot¹, Daniel Marcato¹^,², Christina A. Cramer von Clausbruch¹, Giuseppina Pace¹, Uwe Strähle¹^,³, John K. Colbourne⁴, Christian Pylatiuk⁵, Ravindra Peravali¹, Carsten Weiss¹, Stefan Scholz⁶, Thomas Dickmeis¹

¹Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology - Campus Nord, ²DITABIS AG - Digital Biomedical Imaging Systems AG, ³Centre for Organismal Studies, Heidelberg University, ⁴School of Biosciences, University of Birmingham, ⁵Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology - Campus Nord, ⁶Department of Bioanalytical Ecotoxicology, Helmholtz-Centre for Environmental Research - UFZ

Summary

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Toxicity Evaluation

Zebrafish

Vibration Startle Response

PrecisionTox Consortium

OMICS Data Acquisition

Neuromuscular Toxicity

Chemical Compound Screening

Data Analysis

Benchmark Concentration Values

Modular System

Chapters in this video

0:00

Introduction

1:11

Preparation of Zebrafish Embryos and Chemicals for Testing Neuromuscular and General Toxicity on Embryos