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An Optic Nerve Crush Injury Murine Model to Study Retinal Ganglion Cell Survival

DOI :

10.3791/2685-v

April 25th, 2011

April 25th, 2011

29,666 Views

1National Eye Institute, NIH, 2Ophthalmology Department, The Second Hospital of Harbin Medical University

This protocol shows how to retrogradely label retinal ganglion cells, and how to subsequently make an optic nerve crush injury in order to analyze retinal ganglion cell survival and apoptosis. It is an experimental disease model for different types of optic neuropathy, including glaucoma.

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Optic Nerve Crush Injury

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