The overall goal of this experiment is to develop a new method for generating stem cell-derived inflamed joint associated regulatory T cells for immunotherapy against autoimmune arthritis. This method can help answer key question in the autoimmuni
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We present here a method to develop functional antigen (Ag)-specific regulatory T cells (Tregs) from induced pluripotent stem cells (iPSCs) for immunotherapy of autoimmune arthritis in a murine model.