Stimulation of Responder Cells with Apoptotic and Necrotic Cells
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Results: Inhibition of Phosphorylation of GSK3α/β in BU.MPT Responder Cells Following Exposure to Apoptotic Cells Requires Direct Cell-cell Interaction but Is Independent of Phagocytosis
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Conclusion
Transcription
The overall goal of this procedure is to identify signaling events induced and viable responder cells following their physical interaction with nearby dead cells. This method can help answer key questions in the fields of cell biology, pathology a
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Here, we present a protocol for the determination of intracellular signaling events induced in viable cells by physical interaction with adjacent dead or dying cells. The protocol focuses on signaling events induced by receptor-mediated recognition of the dead cells, as opposed to their phagocytic uptake or release of soluble mediators.