Microelectrode Array System Preparation for Recording
4:18
Heart Tissue Placement on Microelectrode Array Grid
5:03
Data Acquisition
6:10
Analysis of Microelectrode Array Recordings for Sinoatrial Node Beat Frequency Measurement
7:13
Results: The Sinoatrial Node Beat Frequency Measurement
8:41
Conclusion
Transcription
Measuring intrinsic heart rate is an important indicator of cardiac health. This technique accurately measures this rate while excluding the majority of confounding influences on the sinoatrial node. MEA recording of intrinsic heart rate captures
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This protocol aims to describe a new methodology to measure intrinsic cardiac firing rate using microelectrode array recording of the whole sinoatrial node tissue to identify pacemaking defects in mice. Pharmacological agents can also be introduced in this method to study their effects on intrinsic pacemaking.