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Chapter 26

The Cytoskeleton II: Microtubules and Intermediate Filaments

Microtubuli
Microtubuli
Microtubules are the thickest cytoskeletal filaments with a diameter of 25 nm. In prokaryotic organisms, microtubules are commonly found in locomotory ...
Instabilità dei microtubuli
Instabilità dei microtubuli
Microtubules are hollow cylindrical filaments having a diameter of approximately 25 nm and a length that varies from 200 nm to 25 μm. GTP-bound ...
Formazione di microtubuli
Formazione di microtubuli
Microtubules are dynamic structures that undergo continuous assembly and disassembly. They originate from specialized multi-protein complexes known as ...
Proteine associate ai microtubuli (MAP)
Proteine associate ai microtubuli (MAP)
Microtubule function and architecture are regulated by an array of specialized proteins called microtubule-associated proteins or MAPs. These proteins are ...
Destabilizzazione dei microtubuli
Destabilizzazione dei microtubuli
The destabilization of microtubules can occur during different stages of the microtubule lifecycle, such as nucleation or elongation. It can take place at ...
Proteine motorie associate ai microtubuli
Proteine motorie associate ai microtubuli
Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they ...
Il movimento di organelli e vescicole
Il movimento di organelli e vescicole
In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These ...
Assemblaggio di strutture complesse di microtubuli
Assemblaggio di strutture complesse di microtubuli
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular ...
Microtubuli nella motilità cellulare
Microtubuli nella motilità cellulare
Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form ...
Meccanismo del movimento ciliare
Meccanismo del movimento ciliare
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible ...
Microtubuli nella segnalazione
Microtubuli nella segnalazione
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like ...
Farmaci che stabilizzano i microtubuli
Farmaci che stabilizzano i microtubuli
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the ...
Farmaci che destabilizzano i microtubuli
Farmaci che destabilizzano i microtubuli
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that ...
La struttura dei filamenti intermedi
La struttura dei filamenti intermedi
The intermediate filaments are one of three widely studied cytoskeletal filaments. They are so named as their diameter (10 nm) is in between that of ...
Tipi di filamenti intermedi
Tipi di filamenti intermedi
The intermediate filaments are an essential component of the cytoskeleton. Presently six types of intermediate filament have been identified. Type I and ...
Formazione di filamenti intermedi
Formazione di filamenti intermedi
Intermediate filaments are cytoskeletal proteins with higher tensile strength and flexibility than microfilaments and microtubules. Unlike the other two ...
Smontaggio dei filamenti intermedi
Smontaggio dei filamenti intermedi
Intermediate filaments (IFs) do not undergo spontaneous disassembly. Enzymes, kinases, and phosphatases add and remove phosphates from specific sites to ...
Septine
Septine
Septins are protein filaments forming the cytoskeleton along with the microtubules, microfilaments, intermediate filaments, and other accessory proteins. ...
Ruolo delle septine
Ruolo delle septine
Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate ...
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