The overall goal of this experimental protocol is to rapidly evaluate multiple treatment conditions affecting perineural invasion in head and neck squamous cancer with very high assay success rates and reproducibility. This method can help answer
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Perineural invasion (PNI) is a common feature of head and neck squamous cell carcinoma (HNSCC), conferring lower survival rates. Its mechanisms are poorly understood. Utilizing neurites generated from murine dorsal root ganglia confined to a semisolid matrix, the pathways involved in the PNI of HNSCC cell lines can be investigated.