Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

1.1K Views

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06:51 min

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July 28th, 2023

DOI :

10.3791/65605-v

July 28th, 2023

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Lauren C. Frazer¹, Yukihiro Yamaguchi¹, Corey M. Jania¹, Wyatt E. Lanik², Qingqing Gong³, Dhirendra K. Singh¹, Stephen Mackay¹, Natalia S. Akopyants¹, Misty Good¹

¹Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of North Carolina at Chapel Hill, ²University of Nebraska College of Medicine, ³Department of Surgery, Washington University School of Medicine

Transcript

Summary

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Microfluidic Model

Necrotizing Enterocolitis

Human Neonatal Intestinal Enteroids

Gut Barrier Permeability

Microbial Dysbiosis

Inflammation Dysregulation

In Vitro Models

Pathophysiology

Drug Discovery Testing

Chapters in this video

0:00

Introduction

0:48

Microfluidic Necrotizing Enterocolitis on‐a‐Chip Model for Studying NEC Pathophysiology

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