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JoVE Journal

Behavior

This content is Open Access.

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

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09:29 min

January 9th, 2015

January 9th, 2015

15,241 Views

0:05

Title

1:50

Handling and Food Restriction

2:33

Magazine Training

3:56

Lever Press Training: Pre-training Stage

5:19

Lever Press Training: Lever Press Training on a Discrete Trial Schedule

6:23

Signal Attentuation and Regular Extinction

7:03

Testing

7:45

Results: Alterations in Signal Attentuation after Drug Intervention

8:32

Conclusion

The goal of the protocol described in this paper is to induce compulsive-like behavior in rats for the study of obsessive-compulsive disorder (OCD). This behavior is precipitated by attenuating a signal indicating that a lever-press response was effective in producing food.

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