Department of Experimental Oncology
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The DNA chaperone HMGB1 facilitates ACF/CHRAC-dependent nucleosome sliding.
The EMBO journal Dec, 2002 | Pubmed ID: 12486007
Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion.
The EMBO journal Oct, 2003 | Pubmed ID: 14532127
The use of mass spectrometry for the analysis of histone modifications.
Methods in enzymology , 2004 | Pubmed ID: 14979021
The N-terminus of Drosophila SU(VAR)3-9 mediates dimerization and regulates its methyltransferase activity.
Biochemistry Mar, 2004 | Pubmed ID: 15035645
A combination of different mass spectroscopic techniques for the analysis of dynamic changes of histone modifications.
Proteomics May, 2004 | Pubmed ID: 15188406
The long acidic tail of high mobility group box 1 (HMGB1) protein forms an extended and flexible structure that interacts with specific residues within and between the HMG boxes.
Biochemistry Sep, 2004 | Pubmed ID: 15379539
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer.
Nature genetics Apr, 2005 | Pubmed ID: 15765097
Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.
Nature chemical biology Aug, 2005 | Pubmed ID: 16408017
"Chromatomics" the analysis of the chromatome.
Molecular bioSystems Jul, 2005 | Pubmed ID: 16880972
PTMs on H3 variants before chromatin assembly potentiate their final epigenetic state.
Molecular cell Oct, 2006 | Pubmed ID: 17052464
Site-specific acetylation of ISWI by GCN5.
BMC molecular biology , 2007 | Pubmed ID: 17760996
Iodoacetamide-induced artifact mimics ubiquitination in mass spectrometry.
Nature methods Jun, 2008 | Pubmed ID: 18511913
Quantitative proteomics as a new piece of the systems biology puzzle.
Journal of proteomics Aug, 2008 | Pubmed ID: 18640294
Combined use of RNAi and quantitative proteomics to study gene function in Drosophila.
Molecular cell Sep, 2008 | Pubmed ID: 18775334
Systems-wide analysis of a phosphatase knock-down by quantitative proteomics and phosphoproteomics.
Molecular & cellular proteomics : MCP Aug, 2009 | Pubmed ID: 19429919
The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin.
EMBO reports Jul, 2009 | Pubmed ID: 19498464
SILAC-based proteomic analysis to dissect the "histone modification signature" of human breast cancer cells.
Amino acids Jul, 2011 | Pubmed ID: 20617350
Systems biology "on-the-fly": SILAC-based quantitative proteomics and RNAi approach in Drosophila melanogaster.
Methods in molecular biology (Clifton, N.J.) , 2010 | Pubmed ID: 20824466
Substantial histone reduction modulates genomewide nucleosomal occupancy and global transcriptional output.
PLoS biology Jun, 2011 | Pubmed ID: 21738444
Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells.
Nucleic acids research Apr, 2012 | Pubmed ID: 22210892
Methylation of CenH3 arginine 37 regulates kinetochore integrity and chromosome segregation.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2012 | Pubmed ID: 22615363
The proteomic investigation of chromatin functional domains reveals novel synergisms among distinct heterochromatin components.
Molecular & cellular proteomics : MCP Mar, 2013 | Pubmed ID: 23319141
Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells.
Molecular cell Feb, 2013 | Pubmed ID: 23352454
Reply to "Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases".
Nature chemical biology Mar, 2013 | Pubmed ID: 23416388
Mass spectrometry-based proteomics for the analysis of chromatin structure and dynamics.
International journal of molecular sciences , 2013 | Pubmed ID: 23466885
Cell reprogramming requires silencing of a core subset of polycomb targets.
PLoS genetics , 2013 | Pubmed ID: 23468641
Mass spectrometry-based identification and characterisation of lysine and arginine methylation in the human proteome.
Molecular bioSystems Sep, 2013 | Pubmed ID: 23748837
Threshold-controlled ubiquitination of the EGFR directs receptor fate.
The EMBO journal Jul, 2013 | Pubmed ID: 23799367
Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity.
Molecular cell Jan, 2014 | Pubmed ID: 24289921
Biochemical systems approaches for the analysis of histone modification readout.
Biochimica et biophysica acta Mar, 2014 | Pubmed ID: 24681439
Quantitative chemical proteomics identifies novel targets of the anti-cancer multi-kinase inhibitor E-3810.
Molecular & cellular proteomics : MCP Apr, 2014 | Pubmed ID: 24696502
Proteomics meets genetics: SILAC labeling of Drosophila melanogaster larvae and cells for in vivo functional studies.
Methods in molecular biology (Clifton, N.J.) , | Pubmed ID: 25059620
Improved bottom-up strategy to efficiently separate hypermodified histone peptides through ultra-HPLC separation on a bench top Orbitrap instrument.
Proteomics , | Pubmed ID: 25073962
ARGONAUTE2 cooperates with SWI/SNF complex to determine nucleosome occupancy at human Transcription Start Sites.
Nucleic acids research , | Pubmed ID: 25605800
Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth.
Oncotarget , | Pubmed ID: 26429879
Pathology Tissue-quantitative Mass Spectrometry Analysis to Profile Histone Post-translational Modification Patterns in Patient Samples.
Molecular & cellular proteomics : MCP , | Pubmed ID: 26463340
miR-17-92 fine-tunes MYC expression and function to ensure optimal B cell lymphoma growth.
Nature communications , | Pubmed ID: 26555894
The contribution of mass spectrometry-based proteomics to understanding epigenetics.
Epigenomics , | Pubmed ID: 26606673
Recent advances in mass spectrometry analysis of histone post-translational modifications: potential clinical impact of the PAT-H-MS approach.
Expert review of proteomics , | Pubmed ID: 26822344
MS-analysis of SILAC-labeled MYC-driven B lymphoma cells overexpressing miR-17-19b.
Data in brief , | Pubmed ID: 26977435
MYC/miR-17-92 interplay maintains B-lymphoma cell homeostasis.
Cell cycle (Georgetown, Tex.) , | Pubmed ID: 27097369
The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death.
Nature medicine , | Pubmed ID: 27135741
Spatiotemporal plasticity of miRNAs functions: The miR-17-92 case.
Molecular & cellular oncology , | Pubmed ID: 27314099
Quantitative assessment of chemical artefacts produced by propionylation of histones prior to mass spectrometry analysis.
Proteomics , | Pubmed ID: 27373704
Mass-spectrometry analysis of histone post-translational modifications in pathology tissue using the PAT-H-MS approach.
Data in brief , | Pubmed ID: 27408908
SILAC-Based Quantitative Strategies for Accurate Histone Posttranslational Modification Profiling Across Multiple Biological Samples.
Methods in molecular biology (Clifton, N.J.) , | Pubmed ID: 27854018
High constitutive activity of a broad panel of housekeeping and tissue-specific -regulatory elements depends on a subset of ETS proteins.
Genes & development , | Pubmed ID: 28275002
PAT-H-MS coupled with laser microdissection to study histone post-translational modifications in selected cell populations from pathology samples.
Clinical epigenetics , | Pubmed ID: 28702092
Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.
ACS medicinal chemistry letters , | Pubmed ID: 28835804
Chromatin proteomics reveals novel combinatorial histone modification signatures that mark distinct subpopulations of macrophage enhancers.
Nucleic acids research , | Pubmed ID: 28981749
A role for CENP-A/Cse4 phosphorylation on serine 33 in deposition at the centromere.
FEMS yeast research , | Pubmed ID: 29272409
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases.
Nature communications 01, 2018 | Pubmed ID: 29317660
PARP14 Controls the Nuclear Accumulation of a Subset of Type I IFN-Inducible Proteins.
Journal of immunology (Baltimore, Md. : 1950) , | Pubmed ID: 29500242
Zc3h10 is a novel mitochondrial regulator.
EMBO reports , | Pubmed ID: 29507079
Extensive and systematic rewiring of histone post-translational modifications in cancer model systems.
Nucleic acids research , | Pubmed ID: 29618087
The kinetochore module Okp1/Ame1 is a reader for N-terminal modifications on the centromeric histone Cse4.
The EMBO journal , | Pubmed ID: 30389668
Mass Spectrometry-Based Proteomics to Unveil the Non-coding RNA World.
Frontiers in molecular biosciences , | Pubmed ID: 30467545
Alternative digestion approaches improve histone modification mapping by mass spectrometry in clinical samples.
Proteomics. Clinical applications , | Pubmed ID: 30471193
hmSEEKER: Identification of hmSILAC Doublets in MaxQuant Output Data.
Proteomics , | Pubmed ID: 30656827
Proteomics profiling of arginine methylation defines PRMT5 substrate specificity.
Science signaling , | Pubmed ID: 30940768
Profiling of Epigenetic Features in Clinical Samples Reveals Novel Widespread Changes in Cancer.
Cancers , | Pubmed ID: 31137727
Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.
Cancer cell , | Pubmed ID: 31408619
hSWATH: Unlocking SWATH's Full Potential for an Untargeted Histone Perspective.
Journal of proteome research , | Pubmed ID: 31429292
Epigenetic drug target deconvolution by mass spectrometry-based technologies.
Nature structural & molecular biology , | Pubmed ID: 31582842
Enrichment of histones from patient samples for mass spectrometry-based analysis of post-translational modifications.
Methods (San Diego, Calif.) , | Pubmed ID: 31605746
PRMT1-mediated methylation of the microprocessor-associated proteins regulates microRNA biogenesis.
Nucleic acids research , | Pubmed ID: 31777917
PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin.
Cell reports , | Pubmed ID: 31995759
Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation.
Science advances , | Pubmed ID: 32284990
Biochemical and Computational Approaches for the Large-Scale Analysis of Protein Arginine Methylation by Mass Spectrometry.
Current protein & peptide science , | Pubmed ID: 32338214
Clinical Application of Mass Spectrometry-Based Proteomics in Lung Cancer Early Diagnosis.
Proteomics. Clinical applications , | Pubmed ID: 32418314
Software Options for the Analysis of MS-Proteomic Data.
Methods in molecular biology (Clifton, N.J.) , 2021 | Pubmed ID: 34236654
Spatial epi-proteomics enabled by histone post-translational modification analysis from low-abundance clinical samples.
Clinical epigenetics 07, 2021 | Pubmed ID: 34315505
Native Chromatin Proteomics (N-ChroP) to Characterize Histone Post-translational Modification (PTM) Combinatorics at Distinct Genomic Regions.
Methods in molecular biology (Clifton, N.J.) , 2021 | Pubmed ID: 34382194
Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML.
Oncogene 02, 2022 | Pubmed ID: 34862459
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