Michael D. Cahalan

Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel.

The ins and outs of polycystin-2 as a calcium release channel.

Two-photon imaging of lymphocyte motility and antigen response in intact lymph node.

Distinct properties of CRAC and MIC channels in RBL cells.

Two-photon imaging in intact lymphoid tissue.

Two-photon tissue imaging: seeing the immune system in a fresh light.

A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes.

MIC channels are inhibited by internal divalent cations but not ATP.

Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy.

Polyvalent cations as permeant probes of MIC and TRPM7 pores.

Real-time imaging of lymphocytes in vivo.

A stochastic view of lymphocyte motility and trafficking within the lymph node.

Regulation of membrane trafficking and subcellular organization of endocytic compartments revealed with FM1-43 in resting and activated human T cells.

SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels.

T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node.

A store-operated calcium channel in Drosophila S2 cells.

K+ channels as targets for specific immunomodulation.

Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes.

STOP! In the name of positive selection.

Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1.

Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells.

STIM1, an essential and conserved component of store-operated Ca2+ channel function.

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane.

Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels.

Close encounters of the first and second kind: T-DC and T-B interactions in the lymph node.

Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses.

The sense of place in the immune system.

Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity.

Imaging the choreography of lymphocyte trafficking and the immune response.

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.

Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai.

Molecular basis of the CRAC channel.

Natural killer cells actively patrol peripheral lymph nodes forming stable conjugates to eliminate MHC-mismatched targets.

Ca2+ signals in CD4+ T cells during early contacts with antigen-bearing dendritic cells in lymph node.

Class IA phosphoinositide 3-kinase modulates basal lymphocyte motility in the lymph node.

Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs.

Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation.

Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3.

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers.

Quantum dots for tracking dendritic cells and priming an immune response in vitro and in vivo.

Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block.

A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension.

STIMulating store-operated Ca(2+) entry.

The functional network of ion channels in T lymphocytes.

NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity.

The immunological synapse: a dynamic platform for local signaling.

Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th1- and Th2-polarizing adjuvants.

Cell biology. How to STIMulate calcium channels.

Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells.

Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.

General approach to adoptive transfer and cell labeling for immunoimaging.

Induction of an immune response for imaging antigen-presenting cell/T-cell interactions.

In situ lymph node imaging.

In vivo lymph node imaging.

Immunoimaging: studying immune system dynamics using two-photon microscopy.

Imaging transplant rejection: a new view.

Analysis of transient migration behavior of natural killer cells imaged in situ and in vitro.

Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91.

Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states.

CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation.